Alazanine

Alazanine

SCHEMBL1506900

CCN1/C(=C\C=C\c2sc3ccccc3[n+]2CC)Sc2ccccc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 1.00
KMT2A Q03164 5/20 1.00
HTT P42858 4/20 1.00
BLM P54132 4/20 1.00
APP P05067 7/20 0.98
NPC1 O15118 5/20 0.98
RAB9A P51151 5/20 0.98
APAF1 O14727 2/20 0.98
ITGB2 P05107 1/20 0.98
ALPL P05186 1/20 0.98
ITGAM P11215 1/20 0.98
GFER P55789 1/20 0.98
L3MBTL1 Q9Y468 1/20 0.98
ALDH1A1 P00352 2/20 0.90
POLB P06746 2/20 0.90
MAPT P10636 2/20 0.90
THRB P10828 2/20 0.90
PKM P14618 2/20 0.90
RECQL P46063 2/20 0.90
SMN1; SMN2 Q16637 2/20 0.90

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Alazanine SCHEMBL12364489 1.00 MEN1 (1.00) MEN1KMT2AHTTBLMAPP
Alazanine SCHEMBL10020546 1.00 MEN1 (1.00) MEN1KMT2AHTTBLMAPP
Alazanine SCHEMBL30133356 1.00 MEN1 (1.00) MEN1KMT2AHTTBLMAPP
Alazanine SCHEMBL1506901 1.00 MEN1 (1.00) MEN1KMT2AHTTBLMAPP
Alazanine SCHEMBL142862 0.99 APP (1.00) MEN1KMT2AHTTBLMAPP
Alazanine SCHEMBL11690918 0.99 MEN1 (0.98) MEN1KMT2AHTTBLMAPP
Alazanine SCHEMBL29887077 0.99 APP (1.00) MEN1KMT2AHTTBLMAPP
Alazanine SCHEMBL31179678 0.99 MEN1 (0.98) MEN1KMT2AHTTBLMAPP
Alazanine SCHEMBL29556313 0.99 APP (1.00) MEN1KMT2AHTTBLMAPP
Alazanine SCHEMBL5453750 0.99 APP (1.00) MEN1KMT2AHTTBLMAPP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024118805-A1 TOPOISOMERASE III (TOP3) INHIBITORS AND ANTIVIRAL COMPOUNDS BASED ON CYANINES THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2024-06-06 WO disclosed
US-10041937-B2 Macrophage identification agent, and identification method, sorting method, evaluation method, screening method and kit using the macrophage identifier agent CANON KABUSHIKI KAISHA (JP) 2018-08-07 US disclosed
US-20170340622-A1 METHOD OF DETECTING CANCER STEM CELL, METHOD OF SCREENING CANCER STEM CELL, AND METHOD OF INHIBITING CANCER STEM CELL CANON KK (JP) 2017-11-30 US disclosed
US-20170340622-A1 METHOD OF DETECTING CANCER STEM CELL, METHOD OF SCREENING CANCER STEM CELL, AND METHOD OF INHIBITING CANCER STEM CELL CANON KK (JP) 2017-11-30 US disclosed
US-9764046-B2 Labeling composition for intraocular tissue, labeling method of intraocular tissue, and screening method CANON KABUSHIKI KAISHA (JP) 2017-09-19 US disclosed
US-20160018389-A1 MACROPHAGE IDENTIFICATION AGENT, AND IDENTIFICATION METHOD, SORTING METHOD, EVALUATION METHOD, SCREENING METHOD AND KIT USING THE MACROPHAGE IDENTIFIER AGENT CANON KABUSHIKI KAISHA (JP) 2016-01-21 US disclosed
US-20160018389-A1 MACROPHAGE IDENTIFICATION AGENT, AND IDENTIFICATION METHOD, SORTING METHOD, EVALUATION METHOD, SCREENING METHOD AND KIT USING THE MACROPHAGE IDENTIFIER AGENT CANON KABUSHIKI KAISHA (JP) 2016-01-21 US disclosed
US-20150182518-A1 CANCER CELL INHIBITORY DRUG AND CANCER STEM-CELL DETECTION PROBE CANON KABUSHIKI KAISHA (JP) 2015-07-02 US disclosed
US-20150182518-A1 CANCER CELL INHIBITORY DRUG AND CANCER STEM-CELL DETECTION PROBE CANON KABUSHIKI KAISHA (JP) 2015-07-02 US disclosed
US-20150139908-A1 LABELING COMPOSITION FOR INTRAOCULAR TISSUE, LABELING METHOD OF INTRAOCULAR TISSUE, AND SCREENING METHOD CANON KK (JP) 2015-05-21 US disclosed
US-20110236310-A1 LABELING COMPOSITION FOR INTRAOCULAR TISSUE, LABELING METHOD OF INTRAOCULAR TISSUE, AND SCREENING METHOD CANON KABUSHIKI KAISHA (JP) 2011-09-29 US disclosed
US-20110190480-A1 CYANOBORATE, FLUOROALKYLPHOSPHATE, FLUOROALKYLBORATE OR IMIDE DYES IGNATYEV NIKOLAI MYKOLA 2011-08-04 US disclosed
US-7939644-B2 cationic dyes used for coloring plastics, fibers, leather and paper, for the preparation of flexographic printing inks, as ball-point pen pastes, as stamp inks, for use in data acquisition systems, reprography, in ink microfilters, in photogalvanics, laser technology and the photo industry MERCK PATENT GMBH (DE) 2011-05-10 US disclosed
US-7939644-B2 cationic dyes used for coloring plastics, fibers, leather and paper, for the preparation of flexographic printing inks, as ball-point pen pastes, as stamp inks, for use in data acquisition systems, reprography, in ink microfilters, in photogalvanics, laser technology and the photo industry MERCK PATENT GMBH (DE) 2011-05-10 US disclosed
EP-2292700-A1 Cyanoborate dyes Merck Patent GmbH (DE) 2011-03-09 EP disclosed
US-20100166663-A1 PROBE FOR A HAIR CELL, AND LABELLING METHOD FOR A HAIR CELL USING THE PROBE FOR A HAIR CELL CANON KABUSHIKI KAISHA (JP) 2010-07-01 US disclosed
US-20080275224-A1 Cyanoborate, Fluoroalkylphosphate, Fluoroalkylborate or Imide Dyes MERCK PATENT GMBH (DE) 2008-11-06 US disclosed
US-20080275224-A1 Cyanoborate, Fluoroalkylphosphate, Fluoroalkylborate or Imide Dyes MERCK PATENT GMBH (DE) 2008-11-06 US disclosed
EP-1660591-A1 CYANOBORATE, FLUOROALKYL PHOSPHATE, FLUOROALKYL BORATE OR IMIDE DYES MERCK PATENT GmbH (DE) 2006-05-31 EP disclosed
WO-2005021661-A1 CYANOBORATE, FLUOROALKYL PHOSPHATE, FLUOROALKYL BORATE OR IMIDE DYES MERCK PATENT GMBH (DE) 2005-03-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110190480-A1 CYANOBORATE, FLUOROALKYLPHOSPHATE, FLUOROALKYLBORATE OR IMIDE DYES ZAP70, MYLK3, KIT MEN1 4104/4885KMT2A 823/4885HTT 3056/4885
US-20110236310-A1 LABELING COMPOSITION FOR INTRAOCULAR TISSUE, LABELING METHOD OF INTRAOCULAR TISSUE, AND SCREENING METHOD ALDH1A2, PDE6C, CHAT MEN1 2132/4885KMT2A 3911/4885HTT 4042/4885
US-20170340622-A1 METHOD OF DETECTING CANCER STEM CELL, METHOD OF SCREENING CANCER STEM CELL, AND METHOD OF INHIBITING CANCER STEM CELL MKI67, KIT, ALDH1A1 MEN1 2213/4885KMT2A 2616/4885HTT 4650/4885
US-10041937-B2 Macrophage identification agent, and identification method, sorting method, evaluation method, screening method and kit using the macrophage identifier agent CD68, MSR1, MYADM MEN1 1787/4885KMT2A 578/4885HTT 4857/4885
US-20150182518-A1 CANCER CELL INHIBITORY DRUG AND CANCER STEM-CELL DETECTION PROBE MKI67, ABCB1, CD44 MEN1 2178/4885KMT2A 2210/4885HTT 4278/4885
US-20080275224-A1 Cyanoborate, Fluoroalkylphosphate, Fluoroalkylborate or Imide Dyes ZAP70, MYLK3, KIT MEN1 4104/4885KMT2A 823/4885HTT 3056/4885
US-20160018389-A1 MACROPHAGE IDENTIFICATION AGENT, AND IDENTIFICATION METHOD, SORTING METHOD, EVALUATION METHOD, SCREENING METHOD AND KIT USING THE MACROPHAGE IDENTIFIER AGENT CD68, MSR1, MYADM MEN1 1787/4885KMT2A 578/4885HTT 4857/4885
US-20100166663-A1 PROBE FOR A HAIR CELL, AND LABELLING METHOD FOR A HAIR CELL USING THE PROBE FOR A HAIR CELL ALPG, MKI67, KRT18 MEN1 2225/4885KMT2A 3444/4885HTT 3311/4885
US-20150139908-A1 LABELING COMPOSITION FOR INTRAOCULAR TISSUE, LABELING METHOD OF INTRAOCULAR TISSUE, AND SCREENING METHOD ALDH1A2, PDE6C, CHAT MEN1 2132/4885KMT2A 3911/4885HTT 4042/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.