Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Alazanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 1.00 |
| ▸ | NPC1 | O15118 | 5/20 | 1.00 |
| ▸ | RAB9A | P51151 | 5/20 | 1.00 |
| ▸ | APAF1 | O14727 | 2/20 | 1.00 |
| ▸ | ITGB2 | P05107 | 1/20 | 1.00 |
| ▸ | ALPL | P05186 | 1/20 | 1.00 |
| ▸ | ITGAM | P11215 | 1/20 | 1.00 |
| ▸ | GFER | P55789 | 1/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 6/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.98 |
| ▸ | HTT | P42858 | 5/20 | 0.98 |
| ▸ | BLM | P54132 | 4/20 | 0.98 |
| ▸ | MAPT | P10636 | 3/20 | 0.92 |
| ▸ | THRB | P10828 | 3/20 | 0.92 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.92 |
| ▸ | POLB | P06746 | 2/20 | 0.92 |
| ▸ | PKM | P14618 | 2/20 | 0.92 |
| ▸ | RECQL | P46063 | 2/20 | 0.92 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.92 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alazanine SCHEMBL142862 | 1.00 | APP (1.00) | APPNPC1RAB9AAPAF1ITGB2 | |
| Alazanine SCHEMBL5453750 | 1.00 | APP (1.00) | APPNPC1RAB9AAPAF1ITGB2 | |
| Alazanine SCHEMBL26664759 | 1.00 | APP (1.00) | APPNPC1RAB9AAPAF1ITGB2 | |
| Alazanine SCHEMBL29887077 | 1.00 | APP (1.00) | APPNPC1RAB9AAPAF1ITGB2 | |
| Alazanine SCHEMBL26664756 | 1.00 | APP (1.00) | APPNPC1RAB9AAPAF1ITGB2 | |
| Alazanine SCHEMBL30133356 | 0.99 | MEN1 (1.00) | APPNPC1RAB9AAPAF1ITGB2 | |
| Alazanine SCHEMBL1506901 | 0.99 | MEN1 (1.00) | APPNPC1RAB9AAPAF1ITGB2 | |
| Alazanine SCHEMBL10020546 | 0.99 | MEN1 (1.00) | APPNPC1RAB9AAPAF1ITGB2 | |
| Alazanine SCHEMBL12364489 | 0.99 | MEN1 (1.00) | APPNPC1RAB9AAPAF1ITGB2 | |
| Alazanine SCHEMBL1506900 | 0.99 | MEN1 (1.00) | APPNPC1RAB9AAPAF1ITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4228631-A1 | FLAVI-BLOCK: A PAN-FLAVIVIRUS INHIBITOR | Baden-Württemberg Stiftung gGmbH (DE) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022078602-A1 | FLAVI-BLOCK: A PAN-FLAVIVIRUS INHIBITOR | BADEN-WÜRTTEMBERG STIFTUNG GGMBH (DE) | 2022-04-21 | — | — | WO | disclosed |