Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 16/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 14/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 14/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25274161 | 0.94 | CHRM3 (0.42) | CHRM3CHRM2CHRM1HDAC2HDAC1 | |
| SCHEMBL27917819 | 0.90 | CHRM3 (0.48) | CHRM3CHRM2CHRM1HDAC2HDAC1 | |
| SCHEMBL28779254 | 0.90 | CHRM3 (0.48) | CHRM3CHRM2CHRM1HDAC2HDAC1 | |
| SCHEMBL25518973 | 0.88 | CNR2 (0.40) | CHRM3CHRM2CHRM1HDAC2HDAC1 | |
| SCHEMBL27791277 | 0.85 | ITGB3 (0.41) | CHRM3CHRM2CHRM1ITGB3ITGA2B | |
| SCHEMBL17444433 | 0.85 | CNR2 (0.36) | CHRM3CHRM2CHRM1HDAC2HDAC1 | |
| SCHEMBL17444434 | 0.85 | CNR2 (0.36) | CHRM3CHRM2CHRM1HDAC2HDAC1 | |
| SCHEMBL19267841 | 0.84 | MEN1 (0.46) | HDAC2HDAC1HDAC3 | |
| SCHEMBL25284961 | 0.84 | MEN1 (0.42) | HDAC2HDAC1HDAC3 | |
| SCHEMBL1367746 | 0.83 | HDAC1 (0.38) | CHRM3CHRM2CHRM1HDAC2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108699032-B | Polycyclic TLR7/8 antagonists and their use in the treatment of immune disorders | 默克专利有限公司 | 2022-07-22 | — | — | CN | disclosed |
| CN-113603675-A | Polycyclic TLR7/8 antagonists and their use in the treatment of immune disorders | 默克专利有限公司 | 2021-11-05 | — | — | CN | disclosed |
| CN-106715435-B | Pyrrolopyrimidine derivatives as NR2B nmda receptor antagonist | 卢郡控股(开曼)有限公司 | 2019-10-01 | — | — | CN | disclosed |
| CN-104350055-B | Bicyclic heteroaryl derivatives and application thereof as MNK1 and MNK2 regulator | 新加坡科技研究局 | 2019-05-31 | — | — | CN | disclosed |
| CN-109414421-A | The inhibitor and its application method of indole amine 2,3-dioxygenase | 百时美施贵宝公司 | 2019-03-01 | — | — | CN | disclosed |
| CN-109153636-A | Cyclopropyl-amide compound as dual LSD1/HDAC inhibitor | 朱比连特比利斯有限公司 | 2019-01-04 | — | — | CN | disclosed |
| CN-109071509-A | BENZIMIDAZOLE DERIVATIVES AS MODULATORS OF ROR-GAMMA | 生命医药公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-108699032-A | Polycyclic T L R7/8 antagonists and their use in treating immune disorders | 默克专利有限公司 | 2018-10-23 | — | — | CN | disclosed |
| CN-107987075-A | Cell death inducer for treating cancer and immunity and autoimmune disease | 艾伯维公司 | 2018-05-04 | — | — | CN | disclosed |
| CN-103874700-B | Pyrazolo [3,4-c ] pyridine compounds and methods of use | 霍夫曼-拉罗奇有限公司 | 2018-03-30 | — | — | CN | disclosed |
| CN-101522668-B | Oxyindole derivatives as 5ht4 receptor agonists | PFIZER | 2012-06-06 | — | — | CN | disclosed |
| CN-102471283-A | Flavin derivatives | BIORELIX INC | 2012-05-23 | — | — | CN | disclosed |
| CN-1968946-B | benzimidazolone carboxylic acid derivatives | PFIZER INC. (US) | 2011-12-21 | — | — | CN | disclosed |
| CN-102239159-A | 7-piperidinoalkyl-3,4-dihydroquinolone derivative | TAISHO PHARMACEUTICAL CO LTD | 2011-11-09 | — | — | CN | disclosed |
| EP-2300007-A1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Zalicus Pharmaceuticals Ltd. (CA) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009146540-A1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD (CA) | 2009-12-10 | — | — | WO | disclosed |
| CN-101522668-A | Oxyindole derivatives as 5ht4 receptor agonists | PFIZER JAPAN INC (US) | 2009-09-02 | — | — | CN | disclosed |
| CN-100482659-C | Benzimidazolone compounds having 5-HT4 receptor agonistic activity | PFIZER (US) | 2009-04-29 | — | — | CN | disclosed |
| CN-1968946-A | Benzimidazolone carboxylic acid derivatives | PFIZER (US) | 2007-05-23 | — | — | CN | disclosed |
| CN-1845922-A | Benzimidazolone compounds having 5-HT4 receptor agonistic activity | PFIZER (US) | 2006-10-11 | — | — | CN | disclosed |