Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | SCN4A | P35499 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | TERT | O14746 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14288347 | 0.85 | EGLN1 (0.39) | NCF1KDM1ANPC1SCN4ARAB9A | |
| SCHEMBL14288348 | 0.84 | MCHR1 (0.42) | NCF1KDM1ANPC1SCN4ARAB9A | |
| SCHEMBL14288336 | 0.83 | CRHR1 (0.43) | NCF1NPC1SCN4ARAB9ASMN1; SMN2 | |
| SCHEMBL10122186 | 0.77 | NPC1 (0.43) | KDM1ANPC1SCN4ARAB9ASMN1; SMN2 | |
| SCHEMBL8275784 | 0.77 | CYP1A2 (0.59) | NCF1NPC1RAB9ASMN1; SMN2PSMB5 | |
| SCHEMBL21195656 | 0.77 | NPC1 (0.43) | KDM1ANPC1SCN4ARAB9ASMN1; SMN2 | |
| SCHEMBL889349 | 0.77 | NPC1 (0.43) | KDM1ANPC1SCN4ARAB9ASMN1; SMN2 | |
| SCHEMBL31143623 | 0.77 | CYP1A2 (0.59) | NCF1NPC1RAB9ASMN1; SMN2PSMB5 | |
| SCHEMBL1102403 | 0.77 | CYP1A2 (0.59) | KDM1ANPC1SCN4ARAB9ASMN1; SMN2 | |
| SCHEMBL12938118 | 0.76 | NPC1 (0.48) | KDM1ANPC1SCN4ARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080015190-A1 | Inhibitors of Histone Deacetylase | MERCK SHARP & DOHME CORP. | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015190-A1 | Inhibitors of Histone Deacetylase | HDAC5, HDAC1, HDAC4 | NCF1 591/4885KDM1A 98/4885NPC1 590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.