Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SCN4A | P35499 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14288347 | 0.89 | EGLN1 (0.39) | PDE10ANCF1CRHR1NPC1SCN4A | |
| SCHEMBL14288335 | 0.84 | NCF1 (0.53) | MCHR1PDE10ANCF1NPC1SCN4A | |
| SCHEMBL14288336 | 0.81 | CRHR1 (0.43) | MCHR1PDE10ANCF1CRHR1CASR | |
| SCHEMBL1500184 | 0.78 | BACE1 (0.46) | MCHR1NCF1HCAR3 | |
| SCHEMBL20049185 | 0.73 | PDE10A (0.54) | MCHR1PDE10ANPC1SCN4ARAB9A | |
| SCHEMBL18948584 | 0.72 | PDE10A (0.53) | PDE10ACRHR1NPC1SCN4ARAB9A | |
| SCHEMBL11974254 | 0.71 | NPSR1 (0.41) | CASR | |
| SCHEMBL21195656 | 0.70 | NPC1 (0.43) | PDE10ANPC1SCN4ARAB9ASMN1; SMN2 | |
| SCHEMBL10122186 | 0.70 | NPC1 (0.43) | PDE10ANPC1SCN4ARAB9ASMN1; SMN2 | |
| SCHEMBL889349 | 0.70 | NPC1 (0.43) | PDE10ANPC1SCN4ARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080015190-A1 | Inhibitors of Histone Deacetylase | MERCK SHARP & DOHME CORP. | 2008-01-17 | — | — | US | disclosed |
| US-20080015190-A1 | Inhibitors of Histone Deacetylase | MERCK SHARP & DOHME CORP. | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015190-A1 | Inhibitors of Histone Deacetylase | HDAC5, HDAC1, HDAC4 | MCHR1 3537/4885PDE10A 4311/4885NCF1 591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.