Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.60 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22410707 | 0.89 | KDM4E (0.55) | KDM4EHSP90AA1HSP90AB1NPC1RAB9A | |
| SCHEMBL15140307 | 0.83 | KDM4E (0.71) | KDM4EHSP90AA1HSP90AB1NPC1RAB9A | |
| SCHEMBL8489674 | 0.80 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL15726198 | 0.80 | KMT2A (0.45) | KDM4EHSP90AA1HSP90AB1NPC1RAB9A | |
| SCHEMBL2595570 | 0.77 | CCNE1 (0.47) | KDM4ENPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL14658243 | 0.77 | NOTUM (0.51) | KDM4EALDH1A1CCNE1CDK2CDK5 | |
| SCHEMBL7244914 | 0.77 | ALDH1A1 (0.56) | KDM4ERAB9ASMN1; SMN2ALDH1A1CCNE1 | |
| SCHEMBL4108874 | 0.77 | KDR (0.63) | KDM4ENPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL305046 | 0.76 | NOTUM (0.52) | KDM4ESMN1; SMN2ALDH1A1HSD17B10CCNE1 | |
| SCHEMBL32672056 | 0.76 | NOTUM (0.52) | KDM4ESMN1; SMN2ALDH1A1HSD17B10CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008015423-A1 | QUINOLINE AND QUINOXALINE N-OXIDES AS CHK-1 INHIBITORS | SENTINEL ONCOLOGY LIMITED (GB) | 2008-02-07 | — | — | WO | disclosed |