Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | WNT3A | P56704 | 1/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18058629 | 0.82 | CCNE1 (0.48) | NOTUMALDH1A1KDM4ECCNE1CDK2 | |
| SCHEMBL2841751 | 0.82 | NOTUM (0.57) | NOTUMABL1CHEK1ALDH1A1KDM4E | |
| SCHEMBL30481268 | 0.79 | GSK3B (0.71) | ABL1 | |
| SCHEMBL28166698 | 0.79 | GSK3B (0.60) | NOTUMABL1CHEK1ALDH1A1KDM4E | |
| SCHEMBL30636341 | 0.79 | GSK3B (0.60) | NOTUMABL1CHEK1ALDH1A1KDM4E | |
| SCHEMBL24456557 | 0.79 | MTOR (0.49) | NOTUMALDH1A1KDM4EMTORCCNE1 | |
| SCHEMBL15890212 | 0.79 | KMT2A (0.48) | NOTUMABL1ALDH1A1KDM4EMTOR | |
| SCHEMBL2595570 | 0.78 | CCNE1 (0.47) | ALDH1A1KDM4ECCNE1CDK2CDK5 | |
| SCHEMBL7244914 | 0.78 | ALDH1A1 (0.56) | ALDH1A1KDM4ETRPV1MAOBCCNE1 | |
| SCHEMBL4589056 | 0.78 | HDAC6 (0.65) | ABL1CHEK1KDM4EMTORKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9029378-B2 | Substituted bicyclic aromatic carboxamide and urea compounds as vanilloid receptor ligands | GRUENENTHAL GMBH (DE) | 2015-05-12 | — | — | US | disclosed |
| US-9029378-B2 | Substituted bicyclic aromatic carboxamide and urea compounds as vanilloid receptor ligands | GRUENENTHAL GMBH (DE) | 2015-05-12 | — | — | US | disclosed |
| EP-2736899-A1 | SUBSTITUTED BICYCLIC AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2014-06-04 | — | — | EP | disclosed |
| US-20130029995-A1 | Substituted Bicyclic Aromatic Carboxamide and Urea Compounds as Vanilloid Receptor Ligands | GRUENENTHAL GMBH (DE) | 2013-01-31 | — | — | US | disclosed |
| US-20130029995-A1 | Substituted Bicyclic Aromatic Carboxamide and Urea Compounds as Vanilloid Receptor Ligands | GRUENENTHAL GMBH (DE) | 2013-01-31 | — | — | US | disclosed |
| WO-2013013816-A1 | SUBSTITUTED BICYCLIC AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2013-01-31 | — | — | WO | disclosed |
| WO-2013013816-A1 | SUBSTITUTED BICYCLIC AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2013-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130029995-A1 | Substituted Bicyclic Aromatic Carboxamide and Urea Compounds as Vanilloid Receptor Ligands | TRPV1, TRPV2, TRPV4 | NOTUM 3964/4885ABL1 3600/4885CHEK1 2392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.