Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.60 |
| ▸ | RAB9A | P51151 | 8/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14291322 | 0.80 | KDM4E (0.60) | NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL28056008 | 0.80 | NPC1 (0.72) | NPC1RAB9AKMT2ANFKB1NFKB2 | |
| SCHEMBL27657075 | 0.78 | KMT2A (0.83) | NPC1RAB9AKMT2ANFKB1NFKB2 | |
| SCHEMBL7244914 | 0.78 | ALDH1A1 (0.56) | RAB9AKMT2ASMN1; SMN2TRPV1 | |
| SCHEMBL10756928 | 0.78 | ALDH1A1 (0.43) | KMT2ASMN1; SMN2TRPV1 | |
| SCHEMBL11884568 | 0.77 | NPC1 (0.68) | NPC1RAB9AKMT2ANFKB1NFKB2 | |
| SCHEMBL30159568 | 0.76 | NPC1 (0.59) | NPC1RAB9AKMT2ANFKB1NFKB2 | |
| SCHEMBL6257291 | 0.76 | NPC1 (1.00) | NPC1RAB9AKMT2ANFKB1NFKB2 | |
| Hydrochloric Acid SCHEMBL5505787 | 0.76 | NPC1 (0.66) | NPC1RAB9AKMT2ANFKB1NFKB2 | |
| SCHEMBL59718 | 0.75 | GRM5 (0.62) | NPC1RAB9AKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9029378-B2 | Substituted bicyclic aromatic carboxamide and urea compounds as vanilloid receptor ligands | GRUENENTHAL GMBH (DE) | 2015-05-12 | — | — | US | disclosed |
| US-9029378-B2 | Substituted bicyclic aromatic carboxamide and urea compounds as vanilloid receptor ligands | GRUENENTHAL GMBH (DE) | 2015-05-12 | — | — | US | disclosed |
| EP-2736899-A1 | SUBSTITUTED BICYCLIC AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2014-06-04 | — | — | EP | disclosed |
| US-20130029995-A1 | Substituted Bicyclic Aromatic Carboxamide and Urea Compounds as Vanilloid Receptor Ligands | GRUENENTHAL GMBH (DE) | 2013-01-31 | — | — | US | disclosed |
| US-20130029995-A1 | Substituted Bicyclic Aromatic Carboxamide and Urea Compounds as Vanilloid Receptor Ligands | GRUENENTHAL GMBH (DE) | 2013-01-31 | — | — | US | disclosed |
| WO-2013013816-A1 | SUBSTITUTED BICYCLIC AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2013-01-31 | — | — | WO | disclosed |
| WO-2013013816-A1 | SUBSTITUTED BICYCLIC AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2013-01-31 | — | — | WO | disclosed |
| WO-1999021835-A1 | QUINOLINE DERIVATIVES AS H+-ATPase INHIBITORS AND AS BONE RESORPTION INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130029995-A1 | Substituted Bicyclic Aromatic Carboxamide and Urea Compounds as Vanilloid Receptor Ligands | TRPV1, TRPV2, TRPV4 | NPC1 686/4885RAB9A 3001/4885KMT2A 3314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.