Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.35 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14291380 | 0.82 | ROCK1 (0.51) | MAPTKDM4ERAD52ALDH1A1POLB | |
| SCHEMBL4578786 | 0.81 | ROCK2 (0.45) | POLBHTTCYP3A4TSHRMAPK1 | |
| SCHEMBL14291381 | 0.77 | MAPT (0.42) | NR4A1MAPTKDM4EALDH1A1POLB | |
| SCHEMBL3749826 | 0.72 | CYP3A4 (0.44) | NR4A1MAPTKDM4ERAD52ALDH1A1 | |
| SCHEMBL29393582 | 0.68 | MEN1 (0.57) | NR4A1MAPTKDM4EALDH1A1HTT | |
| SCHEMBL77110 | 0.68 | MEN1 (0.57) | NR4A1MAPTKDM4EALDH1A1HTT | |
| SCHEMBL31554543 | 0.67 | NCF1 (0.47) | ROCK1 | |
| SCHEMBL22509234 | 0.66 | PGK1 (0.48) | PRKCIGAA | |
| Hydrochloric Acid SCHEMBL6235400 | 0.66 | MEN1 (0.55) | NR4A1MAPTKDM4EALDH1A1HTT | |
| SCHEMBL31116725 | 0.65 | ROCK1 (0.47) | MAPTKDM4EALDH1A1LMNACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008024978-A2 | TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES | SERENEX, INC. (US) | 2008-02-28 | — | — | WO | disclosed |