Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | GCGR | P47871 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28402323 | 0.80 | KMT2A (0.56) | KDM4EALDH1A1NPC1SMN1; SMN2PKM | |
| SCHEMBL6259 | 0.79 | TGFBR1 (0.60) | TGFBR1KDM4EALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL30772298 | 0.79 | TGFBR1 (0.60) | TGFBR1KDM4EALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL4074387 | 0.79 | TGFBR1 (0.77) | RAF1IDO1TGFBR1KDM4EALDH1A1 | |
| SCHEMBL1303881 | 0.78 | TGFBR1 (0.53) | RAF1IDO1TGFBR1KDM4EALDH1A1 | |
| SCHEMBL1303063 | 0.75 | KDM4E (0.46) | RAF1TGFBR1KDM4EALDH1A1NPC1 | |
| SCHEMBL19982677 | 0.75 | F2 (0.65) | KDM4EALDH1A1NPC1SMN1; SMN2PKM | |
| SCHEMBL32660751 | 0.75 | CBFB (0.55) | KDM4EALDH1A1NPC1SMN1; SMN2PKM | |
| SCHEMBL4245430 | 0.75 | CBFB (0.55) | KDM4EALDH1A1NPC1SMN1; SMN2PKM | |
| SCHEMBL32660766 | 0.75 | F2 (0.65) | KDM4EALDH1A1NPC1SMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300438-A1 | IMIDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | Merck Sharp & Dohme Corp. (US) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009152025-A1 | IMIDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK & CO., INC. (US) | 2009-12-17 | — | — | WO | disclosed |