Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 6/20 | 0.77 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.70 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.70 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.70 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.70 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.70 |
| ▸ | GCGR | P47871 | 3/20 | 0.70 |
| ▸ | RAF1 | P04049 | 1/20 | 0.62 |
| ▸ | IDO1 | P14902 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4084561 | 0.89 | TGFBR1 (0.72) | TGFBR1MAPK14ALOX5MAPK13MAPK12 | |
| SCHEMBL4077150 | 0.87 | TGFBR1 (1.00) | TGFBR1MAPK14ALOX5MAPK13MAPK12 | |
| SCHEMBL2649978 | 0.82 | MAPK14 (1.00) | TGFBR1MAPK14ALOX5MAPK13MAPK12 | |
| SCHEMBL19868997 | 0.82 | TGFBR1 (0.74) | TGFBR1MAPK14ALOX5MAPK13MAPK12 | |
| SCHEMBL19868984 | 0.81 | MAPK14 (0.81) | TGFBR1MAPK14ALOX5MAPK13MAPK12 | |
| SCHEMBL4079452 | 0.79 | TGFBR1 (0.71) | TGFBR1MAPK14ALOX5MAPK13MAPK12 | |
| SCHEMBL4153691 | 0.79 | TGFBR1 (0.74) | TGFBR1MAPK14ALOX5MAPK13MAPK12 | |
| SCHEMBL4552086 | 0.79 | RAF1 (0.88) | MAPK14ALOX5MAPK13MAPK12MAPK11 | |
| SCHEMBL1429613 | 0.79 | RAF1 (0.53) | TGFBR1MAPK14ALOX5MAPK13MAPK12 | |
| SCHEMBL29406707 | 0.77 | TGFBR1 (0.64) | TGFBR1MAPK14ALOX5MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099237-A1 | Methods of treating inflammatory diseases | ROCHE PALO ALTO LLC | 2009-04-16 | — | — | US | claimed |
| WO-2009047163-A1 | METHODS OF TREATING INFLAMMATORY DISEASES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-16 | — | — | WO | claimed |
| US-20080146617-A1 | Methods of treating inflammatory diseases | ROCHE PALO ALTO LLC | 2008-06-19 | — | — | US | claimed |
| WO-2008071605-A2 | METHODS OF TREATING INFLAMMATORY DISEASES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-19 | — | — | WO | claimed |
| EP-1771171-A1 | USE OF ALK 5 INHIBITORS TO MODULATE OR INHIBIT MYOSTATIN ACTIVITY LEADING TO INCREASED LEAN TISSUE ACCRETION IN ANIMALS | Schering-Plough Ltd. (CH) | 2007-04-11 | — | — | EP | claimed |
| US-20060194845-A1 | Use of ALK 5 inhibitors to modulate or inhibit myostatin activity leading to increased lean tissue accretion in animals | SCHERING CORPORATION | 2006-08-31 | — | — | US | claimed |
| WO-2006025988-A1 | USE OF ALK 5 INHIBITORS TO MODULATE OR INHIBIT MYOSTATIN ACTIVITY LEADING TO INCREASED LEAN TISSUE ACCRETION IN ANIMALS | SCHERING-PLOUGH LTD. (CH) | 2006-03-09 | — | — | WO | claimed |
| EP-1169317-B1 | TRIARYLIMIDAZOLES | SMITHKLINE BEECHAM CORP (US) | 2003-01-15 | — | — | EP | claimed |
| JP-2002541253-A | — | — | 2002-12-03 | — | — | JP | claimed |
| US-6465493-B1 | SUCH AS 4-(4-(4-FLUOROPHENYL)-5-(2-PYRIDYL)-1-HYDROXY-1H-IMIDAZOL-2-YL)BENZONITRILE; ALK5 MEDIATED DISEASES SUCH AS ARTHRITIS, OSTEOPOROSIS, KIDNEY AND RENAL DISEASES, CONGES-TIVE HEART FAILURE, ULCERS, DIABETIC NEPHROPATHY | SMITHKLINE BEECHAM CORPORATION | 2002-10-15 | — | — | US | claimed |
| EP-1169317-A1 | TRIARYLIMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-01-09 | — | — | EP | claimed |
| WO-2000061576-A1 | TRIARYLIMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 2000-10-19 | — | — | WO | claimed |
| US-20240084258-A1 | METHOD FOR PREPARING BROWN ADIPOCYTE | KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION (JP) | 2024-03-14 | — | — | US | disclosed |
| CN-106459903-B | Preparation method of osteoblast and osteoblast inducer | 京都府公立大学法人 | 2021-04-23 | — | — | CN | disclosed |
| US-20180355319-A1 | METHOD FOR PREPARING BROWN ADIPOCYTE | KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION (JP) | 2018-12-13 | — | — | US | disclosed |
| US-20090099237-A1 | Methods of treating inflammatory diseases | ROCHE PALO ALTO LLC | 2009-04-16 | — | — | US | disclosed |
| EP-1169317-B1 | TRIARYLIMIDAZOLES | SMITHKLINE BEECHAM CORP (US) | 2003-01-15 | — | — | EP | disclosed |
| US-6465493-B1 | SUCH AS 4-(4-(4-FLUOROPHENYL)-5-(2-PYRIDYL)-1-HYDROXY-1H-IMIDAZOL-2-YL)BENZONITRILE; ALK5 MEDIATED DISEASES SUCH AS ARTHRITIS, OSTEOPOROSIS, KIDNEY AND RENAL DISEASES, CONGES-TIVE HEART FAILURE, ULCERS, DIABETIC NEPHROPATHY | SMITHKLINE BEECHAM CORPORATION | 2002-10-15 | — | — | US | disclosed |
| EP-1169317-A1 | TRIARYLIMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-01-09 | — | — | EP | disclosed |
| WO-2000061576-A1 | TRIARYLIMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 2000-10-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194845-A1 | Use of ALK 5 inhibitors to modulate or inhibit myostatin activity leading to increased lean tissue accretion in animals | ALK, ACVR1, MSTN | TGFBR1 56/4885MAPK14 1382/4885ALOX5 355/4885 |
| US-20240084258-A1 | METHOD FOR PREPARING BROWN ADIPOCYTE | FABP4, MAPK1, MAP3K1 | TGFBR1 304/4885MAPK14 40/4885ALOX5 3418/4885 |
| US-20090099237-A1 | Methods of treating inflammatory diseases | CSNK1A1, PACSIN2, CSNK1G1 | TGFBR1 3096/4885MAPK14 718/4885ALOX5 867/4885 |
| US-20080146617-A1 | Methods of treating inflammatory diseases | CSNK1A1, PACSIN2, CSNK1G1 | TGFBR1 3096/4885MAPK14 718/4885ALOX5 867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.