Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.45 |
| ▸ | NOS3 | P29474 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GLI1 | P08151 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.40 |
| ▸ | PRCP | P42785 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL6547534 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL1125864 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL302681 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL419844 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL3097543 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL418934 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL302680 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| D-Proline SCHEMBL18493080 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL1675389 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL1895918 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023077206-A1 | GENETICALLY MODIFIED EPITOPES AND MULTIEPITOPE PROTEINS, IMMUNOGENIC COMPOSITIONS AND USE THEREOF | UNIVERSIDADE FEDERAL DO RIO DE JANEIRO - UFRJ (BR) | 2023-05-11 | — | — | WO | claimed |
| US-7462354-B2 | Method and system for optimizing minigenes and peptides encoded thereby | PHARMEXA INC. (US) | 2008-12-09 | — | — | US | claimed |
| US-20240181045-A1 | Dendritic Cell-Targeting Universal Vaccine for Influenza Infection | UNIVERSITY OF MANITOBA (CA) | 2024-06-06 | — | — | US | disclosed |
| WO-2023077206-A1 | GENETICALLY MODIFIED EPITOPES AND MULTIEPITOPE PROTEINS, IMMUNOGENIC COMPOSITIONS AND USE THEREOF | UNIVERSIDADE FEDERAL DO RIO DE JANEIRO - UFRJ (BR) | 2023-05-11 | — | — | WO | disclosed |
| WO-2023077206-A1 | GENETICALLY MODIFIED EPITOPES AND MULTIEPITOPE PROTEINS, IMMUNOGENIC COMPOSITIONS AND USE THEREOF | UNIVERSIDADE FEDERAL DO RIO DE JANEIRO - UFRJ (BR) | 2023-05-11 | — | — | WO | disclosed |
| WO-2021077215-A1 | DENDRITIC CELL-TARGETING UNIVERSAL VACCINE FOR INFLUENZA INFECTION | UNIVERSITY OF MANITOBA (CA) | 2021-04-29 | — | — | WO | disclosed |
| CN-101384279-B | Anti-amyloid immunogenic compositions, methods and uses | CHIESI FARMACEUTICI S.P.A. (IT) | 2012-02-22 | — | — | CN | disclosed |
| EP-2300494-A1 | ANTI-AMYLOID IMMUNOGENIC COMPOSITIONS, METHODS AND USES | CHIESI FARMACEUTICI S.p.A. (IT) | 2011-03-30 | — | — | EP | disclosed |
| US-20100028353-A1 | ANTI-AMYLOID IMMUNOGENIC COMPOSITIONS, METHODS AND USES | CHIESI FARMACEUTICI S.P.A. (IT) | 2010-02-04 | — | — | US | disclosed |
| WO-2010006720-A1 | ANTI-AMYLOID IMMUNOGENIC COMPOSITIONS, METHODS AND USES | CHIESI FARMACEUTICI S.P.A. (IT) | 2010-01-21 | — | — | WO | disclosed |
| EP-2145898-A1 | Anti-amyloid immunogenic compositions, methods and uses | CHIESI FARMACEUTICI S.p.A. (IT) | 2010-01-20 | — | — | EP | disclosed |
| US-20090186033-A1 | ANTI-AMYLOID IMMUNOGENIC COMPOSITIONS, METHODS AND USES | CHIESI FARMACEUTICI S.P.A (IT) | 2009-07-23 | — | — | US | disclosed |
| US-7507710-B2 | Anti-amyloid immunogenic compositions, methods and uses | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-03-24 | — | — | US | disclosed |
| CN-101384279-A | Anti-amyloid immunogenic compositions, methods and uses | CHIESI FARMA SPA (IT) | 2009-03-11 | — | — | CN | disclosed |
| EP-1996227-A2 | ANTI-AMYLOID IMMUNOGENIC COMPOSITIONS, METHODS AND USES | CHIESI FARMACEUTICI S.p.A. (IT) | 2008-12-03 | — | — | EP | disclosed |
| US-20070224190-A1 | Anti-amyloid immunogenic compositions, methods and uses | CHIESI FARMACEUTICI S.P.A (IT) | 2007-09-27 | — | — | US | disclosed |
| WO-2007096076-A2 | ANTI-AMYLOID IMMUNOGENIC COMPOSITIONS, METHODS AND USES | CHIESI FARMACEUTICI S.P.A. (IT) | 2007-08-30 | — | — | WO | disclosed |