Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.45 |
| ▸ | NOS3 | P29474 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GLI1 | P08151 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.40 |
| ▸ | PRCP | P42785 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL1125864 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL302681 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL419844 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL3097543 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL418934 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL1429909 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL302680 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| D-Proline SCHEMBL18493080 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL1675389 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL1895918 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019190333-A1 | BIOACTIVE GREEN-LIPPED MUSSEL EXTRACTS AND USES THEREOF | SANFORD LIMITED (NZ) | 2019-10-03 | — | — | WO | disclosed |
| EP-1381394-A2 | BIOMATERIALS COMPRISING A MELANOCYTE STIMULATING HORMONE (MSH), AND METHOD OF FORMING | The University Of Sheffield (GB) | 2004-01-21 | — | — | EP | disclosed |
| WO-2002083176-A2 | BIOMATERIALS COMPRISING A MELANOCYTE STIMULATING HORMONE (MSH), AND METHOD OF FORMING | UNIVERSITY OF SHEFFIELD (GB) | 2002-10-24 | — | — | WO | disclosed |
| US-6022958-A | NUCLEOTIDE SEQUENCE CODING EMBRYO CANCER IMMUNOGENS; FOR DETECTION THE PRESENCE OF EMBRYO CANCER IMMUNOGEN; ANTICARCINOGENIC AGENTS | BAYER CORPORATION (US) | 2000-02-08 | — | — | US | disclosed |
| US-6013772-A | IMUNOGLOBULIN THAT BINDS CARCINOEMBRYONIC ANTIGEN POLYPEPTIDE; FOR ATTACHING ANTIBODY TO RADIONUCIDES OR TOXINS; FOR DETECTING CARCINOEMBRYONIC ANTIGEN IN SAMPLE; | BAYER CORPORATION (US) | 2000-01-11 | — | — | US | disclosed |
| US-5843761-A | CDNA coding for carcinoembryonic antigen | BAYER CORPORATION (FORMERLY MOLECULAR DIAGNOSTICS, INC.) (US) | 1998-12-01 | — | — | US | disclosed |
| US-5571710-A | VECTORS AND HYBRIDIZING | BAYER CORPORATION (US) | 1996-11-05 | — | — | US | disclosed |
| US-5274087-A | cDNA coding for carcinoembryonic antigen (CEA) | MOLECULAR DIAGNOSTICS, INC. (US) | 1993-12-28 | — | — | US | disclosed |
| US-4690898-A | DNA coding for a signal peptide and DNA containing the same | Yamane, Kunio (JP) | 1987-09-01 | — | — | US | disclosed |
| US-4663294-A | DNA coding for a signal amino acid sequence and DNA containing the same | Yamane, Kunio (JP) | 1987-05-05 | — | — | US | disclosed |