Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.45 |
| ▸ | NOS3 | P29474 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GLI1 | P08151 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.40 |
| ▸ | PRCP | P42785 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL6547534 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL1125864 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL302681 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL3097543 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL418934 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL1429909 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL302680 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| D-Proline SCHEMBL18493080 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL1675389 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL1895918 | 1.00 | NOS2 (0.45) | NOS2NOS3NOS1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117599023-A | Application of monoterpene compound and derivative thereof in preparing LTA4H regulating medicament and extraction method thereof | 北京医院 | 2024-02-27 | — | — | CN | disclosed |
| US-20190194358-A1 | Synthetic Antibodies | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2019-06-27 | — | — | US | disclosed |
| US-20120316078-A1 | METHODS AND MATERIALS FOR PRODUCING POLYPEPTIDES IN VITRO | ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY | 2012-12-13 | — | — | US | disclosed |
| US-20120065123-A1 | Synthetic Antibodies | NATIONAL INSTITUTES OF HEALTH | 2012-03-15 | — | — | US | disclosed |
| US-20120021967-A1 | SYNTHETIC ANTIBODIES | Arizona Board of Regents, A Body Corporate of the State Of Arizona Acting for and Behalf of Arizona (US) | 2012-01-26 | — | — | US | disclosed |
| WO-2010111299-A2 | SYNTHETIC ANTIBODIES | THE ARIZONA BOARD OF REGENTS A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2010-09-30 | — | — | WO | disclosed |
| WO-2009140039-A2 | SYNTHETIC ANTIBODIES | THE ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2009-11-19 | — | — | WO | disclosed |