Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 5/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16174415 | 0.89 | CYP1A2 (0.51) | KDM4ELMNA | |
| SCHEMBL10635979 | 0.81 | ALDH1A1 (0.49) | ABCB1NPSR1ALDH1A1MAPTPKM | |
| SCHEMBL16348227 | 0.81 | ACHE (0.53) | NPSR1ALDH1A1MAPTKDM4EL3MBTL1 | |
| SCHEMBL12958105 | 0.78 | ADRB2 (0.58) | NPSR1ALDH1A1MAPTKDM4EL3MBTL1 | |
| SCHEMBL9886101 | 0.77 | MAPT (0.60) | NPSR1ALDH1A1MAPTTHRBGPR55 | |
| SCHEMBL9191963 | 0.75 | USP2 (0.48) | NPSR1ALDH1A1MAPTPKMKDM4E | |
| SCHEMBL2149791 | 0.75 | MAPT (0.54) | NPSR1ALDH1A1MAPTGPR55KDM4E | |
| SCHEMBL15801288 | 0.74 | MAPT (0.62) | NPSR1ALDH1A1MAPTTHRBGPR55 | |
| SCHEMBL11121575 | 0.74 | KMT2A (0.61) | ABCB1NPSR1MAPTKDM4EMEN1 | |
| SCHEMBL22304560 | 0.74 | ABCB1 (0.39) | ABCB1NPSR1ALDH1A1MAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021369-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | CHEMBRIDGE RESEARCH LABORATORIES, INC. (US) | 2008-02-21 | — | — | WO | disclosed |