Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 5/20 | 0.43 |
| ▸ | BRAF | P15056 | 4/20 | 0.43 |
| ▸ | FLT3 | P36888 | 3/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12347516 | 0.84 | CYP2C9 (0.41) | CYP2C9KDRBRAFFLT3KIT | |
| SCHEMBL12347487 | 0.83 | CYP2C9 (0.41) | CYP2C9KDRBRAFFLT3KIT | |
| SCHEMBL13958200 | 0.80 | BRAF (0.49) | CYP2C9KDRBRAFFLT3KIT | |
| SCHEMBL306522 | 0.78 | CYP2C9 (0.67) | CYP2C9CYP3A4CCR2 | |
| SCHEMBL14302510 | 0.78 | CYP2C9 (0.39) | CYP2C9KDRBRAFNPSR1HTT | |
| SCHEMBL14310292 | 0.78 | CDK8 (0.40) | CYP2C9KDRBRAFFLT3KIT | |
| SCHEMBL14302514 | 0.76 | KCNN4 (0.35) | CYP2C9KDRBRAFFLT3KIT | |
| SCHEMBL14310293 | 0.73 | ALDH1A1 (0.38) | MAPTCCR2NPC1CNR2 | |
| SCHEMBL305754 | 0.71 | CYP2C9 (0.66) | CYP2C9CYP3A4CCR2 | |
| SCHEMBL305568 | 0.71 | CYP2C9 (0.65) | CYP2C9CYP3A4CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008431-A2 | HETEROARYL SULFONAMIDES AND CCR2/CCR9 | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |