Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.37 |
| ▸ | RHOC | P08134 | 1/20 | 0.37 |
| ▸ | RHOA | P61586 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SLC8A1 | P32418 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 3/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL305823 | 0.83 | CYP2C9 (0.51) | HCRTR1HCRTR2CCR2KCNH2 | |
| SCHEMBL305822 | 0.83 | CYP2C9 (0.51) | HCRTR1HCRTR2CCR2KCNH2 | |
| SCHEMBL10223499 | 0.81 | CCR2 (0.51) | CCR2KCNH2 | |
| SCHEMBL14303613 | 0.73 | CYP2C9 (0.43) | NPC1CCR2CNR2MAPT | |
| SCHEMBL12594498 | 0.73 | CCR2 (0.43) | ALDH1A1HCRTR1HCRTR2CCR2 | |
| SCHEMBL14302514 | 0.72 | KCNN4 (0.35) | ALDH1A1CCR2KCNH2NOTUMMAPT | |
| SCHEMBL14310778 | 0.72 | PDK2 (0.43) | ALDH1A1PDK2HCRTR1HCRTR2RHOC | |
| SCHEMBL12347487 | 0.71 | CYP2C9 (0.41) | ALDH1A1NPC1CCR2MAPT | |
| SCHEMBL10223502 | 0.71 | CCR2 (0.51) | ALDH1A1CCR2KCNH2 | |
| SCHEMBL10223552 | 0.71 | CCR2 (0.51) | ALDH1A1CCR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008431-A2 | HETEROARYL SULFONAMIDES AND CCR2/CCR9 | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |