Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.49 |
| ▸ | KDR | P35968 | 5/20 | 0.49 |
| ▸ | RAF1 | P04049 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 4/20 | 0.35 |
| ▸ | FLT3 | P36888 | 3/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | COMT | P21964 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1189926 | 0.82 | CYP2C9 (0.72) | BRAFKDRRAF1CYP2C9CYP3A4 | |
| SCHEMBL14303613 | 0.80 | CYP2C9 (0.43) | BRAFKDRCYP2C9CYP3A4CCR2 | |
| SCHEMBL12347487 | 0.78 | CYP2C9 (0.41) | BRAFKDRCYP2C9CYP3A4CCR2 | |
| SCHEMBL12347516 | 0.77 | CYP2C9 (0.41) | BRAFKDRCYP2C9CYP3A4CCR2 | |
| SCHEMBL18411608 | 0.76 | CCR2 (0.73) | BRAFKDRRAF1CYP2C9CYP3A4 | |
| SCHEMBL14302514 | 0.71 | KCNN4 (0.35) | BRAFKDRCYP2C9CCR2KIT | |
| SCHEMBL12040684 | 0.71 | CYP2C9 (0.55) | CYP2C9CYP3A4CCR2 | |
| SCHEMBL14302510 | 0.71 | CYP2C9 (0.39) | BRAFKDRCYP2C9CYP3A4CCR2 | |
| SCHEMBL14310292 | 0.70 | CDK8 (0.40) | BRAFKDRRAF1CYP2C9PDGFRB | |
| SCHEMBL14310293 | 0.70 | ALDH1A1 (0.38) | CCR2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009009740-A1 | FUSED HETEROARYL PYRIDYL AND PHENYL BENZENESUFLONAMIDES AS CCR2 MODULATORS FOR THE TREAMENT OF INFLAMMATION | CHEMOCENTRYX, INC. (US) | 2009-01-15 | — | — | WO | disclosed |