Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR9 | P51686 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | RAF1 | P04049 | 2/20 | 0.38 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 2/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3091955 | 0.80 | TSHR (0.60) | CCR9TSHRNAMPTCCR2 | |
| SCHEMBL342853 | 0.67 | F7 (0.50) | KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL28254180 | 0.67 | CSF1R (0.55) | CCR9TSHRKMT2ANAMPTVNN1 | |
| SCHEMBL14303626 | 0.67 | CYP3A4 (0.44) | KMT2ACCR2ALDH1A1 | |
| SCHEMBL305766 | 0.65 | GPR27 (0.46) | BRAFKMT2ARAF1RAB9AALDH1A1 | |
| SCHEMBL19336563 | 0.65 | CCR2 (0.46) | CCR2 | |
| SCHEMBL9602320 | 0.65 | ALDH1A1 (0.51) | TSHRKMT2AALDH1A1 | |
| SCHEMBL307594 | 0.65 | CYP2C9 (0.62) | CCR9TSHRCCR2 | |
| SCHEMBL344999 | 0.64 | CCR9 (0.62) | CCR9KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL19415750 | 0.64 | CCR2 (0.48) | TSHRKMT2ACCR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |