Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP28 | Q96RU2 | 6/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | ALB | P02768 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | SHH | Q15465 | 1/20 | 0.37 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313533 | 0.86 | USP28 (0.44) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL1625028 | 0.85 | USP28 (0.44) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL14313534 | 0.83 | HPGD (0.55) | USP28MAPTNPC1RAB9A | |
| SCHEMBL27756812 | 0.79 | USP28 (0.39) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL1624750 | 0.79 | MAPT (0.44) | NR3C1MAPTNPC1RAB9A | |
| SCHEMBL1624999 | 0.76 | TAS1R3 (0.48) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL1625549 | 0.73 | TP53 (0.40) | — | |
| SCHEMBL1624570 | 0.71 | USP28 (0.51) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL1626436 | 0.71 | EZH2 (0.42) | — | |
| SCHEMBL1623533 | 0.71 | MAPT (0.48) | USP28NR3C1MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008014291-A2 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG SIGNALING PATHWAY MODULATORS | IRM LLC (BM) | 2008-01-31 | — | — | WO | disclosed |