Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1624411 | 0.85 | RAB9A (0.60) | HPGDRAB9ATSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL14305395 | 0.83 | USP28 (0.39) | RAB9ANPC1MAPTUSP28 | |
| SCHEMBL14313533 | 0.79 | USP28 (0.44) | RAB9AMAPTUSP28 | |
| SCHEMBL1624544 | 0.77 | RAB9A (0.48) | HPGDRAB9ATSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL1624596 | 0.77 | HPGD (0.48) | HPGDRAB9ATSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL1625099 | 0.74 | MAPT (0.52) | SMN1; SMN2HTTMAPTKMT2AMEN1 | |
| SCHEMBL1624919 | 0.73 | MAPT (0.45) | TSHRNPC1HTTMAPTKMT2A | |
| SCHEMBL1624693 | 0.72 | MAPT (0.42) | MAPTUSP28 | |
| SCHEMBL1624851 | 0.72 | MAPT (0.43) | HPGDRAB9ATSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL1624738 | 0.72 | MAPT (0.47) | SMN1; SMN2HTTMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008014291-A2 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG SIGNALING PATHWAY MODULATORS | IRM LLC (BM) | 2008-01-31 | — | — | WO | disclosed |