Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | PKM | P14618 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14325852 | 0.77 | NPC1 (0.66) | MEN1KMT2ASMN1; SMN2HTTPKM | |
| SCHEMBL16403927 | 0.76 | ALDH1A1 (0.49) | MEN1KMT2ACYP3A4CYP2C19SMN1; SMN2 | |
| SCHEMBL14684728 | 0.74 | POLB (0.64) | MEN1KMT2AGAAALDH1A1MAPT | |
| SCHEMBL14318297 | 0.74 | LMNA (0.51) | MEN1KMT2ACYP3A4CYP2C19CYP1A2 | |
| SCHEMBL14318296 | 0.74 | HPGD (0.45) | CYP3A4CYP2C19PKMALDH1A1HPGD | |
| SCHEMBL14056619 | 0.73 | ALDH1A1 (0.60) | GAAHTTALDH1A1KDM4EMAPT | |
| SCHEMBL16403944 | 0.73 | NPC1 (0.50) | MEN1KMT2AGAASMN1; SMN2HTT | |
| SCHEMBL16403957 | 0.72 | HSD17B10 (0.52) | MEN1KMT2AL3MBTL1RAB9AHSD17B10 | |
| SCHEMBL14056188 | 0.71 | ALDH1A1 (0.61) | GAASMN1; SMN2HTTALDH1A1KDM4E | |
| SCHEMBL14684758 | 0.71 | LMNA (0.53) | MEN1KMT2AGAASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937065-B2 | Compositions and methods for modulating a kinase | CLEVEXEL PHARMA (FR) | 2015-01-20 | — | — | US | disclosed |
| US-8937065-B2 | Compositions and methods for modulating a kinase | CLEVEXEL PHARMA (FR) | 2015-01-20 | — | — | US | disclosed |
| WO-2012172438-A9 | COMPOSITIONS AND METHODS FOR MODULATING A KINASE | DYNAMIX PHARMACEUTICALS LTD. (IL) | 2013-02-07 | — | — | WO | disclosed |
| WO-2012172438-A2 | COMPOSITIONS AND METHODS FOR MODULATING A KINASE | DYNAMIX PHARMACEUTICALS LTD. (IL) | 2012-12-20 | — | — | WO | disclosed |