SCHEMBL14307293

SCHEMBL14307293

Cc1cccc(C(=O)Nc2cccc(N)c2)c1

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNK3 O14649 13/20 0.79
KCNK9 Q9NPC2 9/20 0.79
KCNH2 Q12809 1/20 0.79
MEN1 O00255 3/20 0.73
KMT2A Q03164 3/20 0.73
RXFP1 Q9HBX9 1/20 0.73
POLB P06746 1/20 0.72
PTGS1 P23219 1/20 0.63
NPC1 O15118 2/20 0.63
RAB9A P51151 2/20 0.63
TP53 P04637 1/20 0.63
L3MBTL1 Q9Y468 1/20 0.62
CYP1A2 P05177 1/20 0.62
CYP3A4 P08684 1/20 0.62
GAA P10253 1/20 0.62
MAPT P10636 1/20 0.62
CYP2C9 P11712 1/20 0.62
CYP2C19 P33261 1/20 0.62
NT5E P21589 1/20 0.61
THRB P10828 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20457020 0.95 KCNK3 (0.82) KCNK3KCNK9KCNH2MEN1KMT2A
SCHEMBL7238124 0.94 MEN1 (0.79) KCNK3KCNK9KCNH2MEN1KMT2A
SCHEMBL308208 0.89 PTGS1 (0.72) KCNK3KCNK9KCNH2MEN1KMT2A
SCHEMBL29568967 0.89 PTGS1 (0.72) KCNK3KCNK9KCNH2MEN1KMT2A
SCHEMBL31171978 0.89 PTGS1 (0.72) KCNK3KCNK9KCNH2MEN1KMT2A
SCHEMBL4253897 0.89 KCNK3 (0.93) KCNK3KCNK9KCNH2MEN1KMT2A
SCHEMBL8403932 0.89 PTGS1 (0.72) KCNK3KCNK9KCNH2MEN1KMT2A
Hydrochloric Acid SCHEMBL11740733 0.87 PTGS1 (0.70) KCNK3KCNK9KCNH2MEN1KMT2A
SCHEMBL677855 0.86 TP53 (0.74) KCNK3KCNK9KCNH2MEN1KMT2A
SCHEMBL30706442 0.86 PTGS1 (0.68) KCNK3KCNK9KCNH2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220193633-A1 USE OF POLYMERIC BEADS TO REMOVE OXIDATIVE COMPOUNDS FROM LIQUIDS AUBURN UNIVERSITY 2022-06-23 US disclosed
US-9656969-B2 Polymer film, retardation film, polarizing plate, liquid crystal display, and compound FUJIFILM CORPORATION (JP) 2017-05-23 US disclosed
US-9656969-B2 Polymer film, retardation film, polarizing plate, liquid crystal display, and compound FUJIFILM CORPORATION (JP) 2017-05-23 US disclosed
US-20160168132-A1 DI(HETERO)ARYLAMIDES AND SULFONAMIDES, METHODS FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF MINORYX THERAPEUTICS S.L. (ES) 2016-06-16 US disclosed
US-20160168132-A1 DI(HETERO)ARYLAMIDES AND SULFONAMIDES, METHODS FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF MINORYX THERAPEUTICS S.L. (ES) 2016-06-16 US disclosed
US-20160159750-A1 POLYMER FILM, RETARDATION FILM, POLARIZING PLATE, LIQUID CRYSTAL DISPLAY, AND COMPOUND FUJIFILM CORPORATION (JP) 2016-06-09 US disclosed
US-20160159750-A1 POLYMER FILM, RETARDATION FILM, POLARIZING PLATE, LIQUID CRYSTAL DISPLAY, AND COMPOUND FUJIFILM CORPORATION (JP) 2016-06-09 US disclosed
EP-3027590-A1 DI(HETERO)ARYLAMIDES AND SULFONAMIDES, METHODS FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF Minoryx Therapeutics S.L. (ES) 2016-06-08 EP disclosed
US-9296877-B2 Polymer film, retardation film, polarizing plate, liquid crystal display, and compound FUJIFILM CORPORATION (JP) 2016-03-29 US disclosed
US-9296877-B2 Polymer film, retardation film, polarizing plate, liquid crystal display, and compound FUJIFILM CORPORATION (JP) 2016-03-29 US disclosed
WO-2015014900-A1 DI(HETERO)ARYLAMIDES AND SULFONAMIDES, METHODS FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF MINORYX THERAPEUTICS S.L. (ES) 2015-02-05 WO disclosed
US-20140363588-A1 POLYMER FILM, RETARDATION FILM, POLARIZING PLATE, LIQUID CRYSTAL DISPLAY, AND COMPOUND FUJIFILM CORPORATION (JP) 2014-12-11 US disclosed
US-20140363588-A1 POLYMER FILM, RETARDATION FILM, POLARIZING PLATE, LIQUID CRYSTAL DISPLAY, AND COMPOUND FUJIFILM CORPORATION (JP) 2014-12-11 US disclosed
US-8871314-B2 Polymer film, retardation film, polarizing plate, liquid crystal display, and compound FUJIFILM CORPORATION (JP) 2014-10-28 US disclosed
US-8871314-B2 Polymer film, retardation film, polarizing plate, liquid crystal display, and compound FUJIFILM CORPORATION (JP) 2014-10-28 US disclosed
US-20130266744-A1 POLYMER FILM, RETARDATION FILM, POLARIZING PLATE, LIQUID CRYSTAL DISPLAY, AND COMPOUND FUJIFILM CORPORATION (JP) 2013-10-10 US disclosed
US-20130266744-A1 POLYMER FILM, RETARDATION FILM, POLARIZING PLATE, LIQUID CRYSTAL DISPLAY, AND COMPOUND FUJIFILM CORPORATION (JP) 2013-10-10 US disclosed
EP-1878727-A1 2-AMINOQUINAZOLINE DERIVATIVES KYOWA HAKKO KOGYO CO., LTD. (JP) 2008-01-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160159750-A1 POLYMER FILM, RETARDATION FILM, POLARIZING PLATE, LIQUID CRYSTAL DISPLAY, AND COMPOUND PYM1, CNKSR1, MYB KCNK3 1692/4885KCNK9 1214/4885KCNH2 921/4885
US-20160168132-A1 DI(HETERO)ARYLAMIDES AND SULFONAMIDES, METHODS FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF GLB1, GBA1, GALC KCNK3 1770/4885KCNK9 1807/4885KCNH2 1509/4885
US-20220193633-A1 USE OF POLYMERIC BEADS TO REMOVE OXIDATIVE COMPOUNDS FROM LIQUIDS LPO, GPX4, CAT KCNK3 3204/4885KCNK9 4218/4885KCNH2 4106/4885
US-20140363588-A1 POLYMER FILM, RETARDATION FILM, POLARIZING PLATE, LIQUID CRYSTAL DISPLAY, AND COMPOUND PYM1, CNKSR1, MYB KCNK3 1702/4885KCNK9 1238/4885KCNH2 865/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.