Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6385324 | 0.83 | CYP19A1 (0.40) | CHRNB2CHRNA4KDM4CCYP19A1CYP11B1 | |
| SCHEMBL18067714 | 0.81 | DRD2 (0.39) | CHRNB2CHRNA4CHRNA7DRD2DRD3 | |
| SCHEMBL6387593 | 0.77 | KDM4C (0.34) | CHRNB2CHRNA4KDM4CCYP19A1CYP11B1 | |
| SCHEMBL14303286 | 0.75 | HTR2A (0.45) | CHRNB2CHRNA4KDM4CCYP19A1CYP11B1 | |
| SCHEMBL6388506 | 0.71 | ADRA2A (0.44) | CHRNB2CHRNA4CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL13343950 | 0.70 | HTR2A (0.43) | CHRNB2CHRNA4CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL6391832 | 0.67 | CYP11B1 (0.44) | KDM4CCYP19A1CYP11B1CYP11B2ADRA2A | |
| SCHEMBL6391836 | 0.67 | CYP11B1 (0.44) | KDM4CCYP19A1CYP11B1CYP11B2ADRA2A | |
| SCHEMBL6388288 | 0.67 | CYP19A1 (0.47) | CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL6384474 | 0.66 | ADRA2A (0.39) | CHRNB2CHRNA4CYP19A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458684-B1 | THERAPEUTIC HETEROCYCLES AS BRADYKININ B2 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2008-01-16 | — | — | EP | disclosed |