Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6387593 | 0.88 | KDM4C (0.34) | CHRNB2CHRNA4CHRNA7CYP19A1CYP11B1 | |
| SCHEMBL6388120 | 0.83 | CHRNB2 (0.39) | CHRNB2CHRNA4CHRNA7CYP19A1CYP11B2 | |
| SCHEMBL6388506 | 0.77 | ADRA2A (0.44) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL4701299 | 0.69 | RET (0.42) | CYP11B2 | |
| SCHEMBL1998256 | 0.67 | IDO1 (0.43) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL14309671 | 0.66 | CHRNB2 (0.38) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL6386914 | 0.64 | CYP19A1 (0.44) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL6386918 | 0.64 | CYP19A1 (0.44) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL6385756 | 0.63 | CYP2D6 (0.40) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL6385324 | 0.63 | CYP19A1 (0.40) | CHRNB2CHRNA4CHRNA7CYP19A1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245503-A1 | Therapeutic heterocycles | ASTRAZENECA AB (SE) | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245503-A1 | Therapeutic heterocycles | OPRK1, RECQL, OPRM1 | ADRA2A 98/4885ADRA2B 125/4885ADRA2C 55/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.