Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | RHOC | P08134 | 1/20 | 0.42 |
| ▸ | RHOA | P61586 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13146439 | 0.83 | CCR2 (0.52) | CCR2KCNH2 | |
| SCHEMBL13146698 | 0.74 | CCR2 (0.53) | CCR2 | |
| SCHEMBL15053501 | 0.74 | ALDH1A1 (0.52) | PDK2ALDH1A1RAB9AKMT2AHPGD | |
| SCHEMBL15053502 | 0.74 | ALDH1A1 (0.52) | PDK2ALDH1A1RAB9AKMT2AHPGD | |
| SCHEMBL13146441 | 0.73 | CCR2 (0.54) | CCR2 | |
| SCHEMBL3095653 | 0.73 | CCR2 (0.55) | CCR2HCRTR1HCRTR2 | |
| SCHEMBL3095535 | 0.72 | CCR2 (0.56) | CCR2 | |
| SCHEMBL14310293 | 0.72 | ALDH1A1 (0.38) | PDK2RHOCRHOAALDH1A1CCR2 | |
| SCHEMBL305822 | 0.71 | CYP2C9 (0.51) | CCR2KCNH2HCRTR1HCRTR2 | |
| SCHEMBL305823 | 0.71 | CYP2C9 (0.51) | CCR2KCNH2HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |