Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 5/20 | 0.49 |
| ▸ | HTR2C | P28335 | 9/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 8/20 | 0.31 |
| ▸ | HTR2B | P41595 | 8/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14312864 | 0.89 | HPGDS (0.39) | HPGDSS1PR1HSP90AA1RORCKDM4E | |
| SCHEMBL14312884 | 0.88 | HPGDS (0.39) | HPGDSCYP2C9RORCMAPTNPSR1 | |
| SCHEMBL14313291 | 0.88 | HPGDS (0.41) | HPGDSHTR2CS1PR1S1PR3HTR2A | |
| SCHEMBL14313041 | 0.87 | HPGDS (0.38) | HPGDSHTR2CHTR2AHTR2BHSP90AA1 | |
| SCHEMBL14313459 | 0.87 | HPGDS (0.42) | HPGDSHSP90AA1 | |
| SCHEMBL14313182 | 0.85 | HPGDS (0.50) | HPGDSS1PR1S1PR3 | |
| SCHEMBL14313085 | 0.85 | HPGDS (0.39) | HPGDSHSP90AA1 | |
| SCHEMBL14313363 | 0.85 | HPGDS (0.47) | HPGDSHTR2CS1PR1S1PR3HTR2A | |
| SCHEMBL14313410 | 0.82 | HPGDS (0.41) | HPGDSHTR2CHTR2AHTR2BCYP2C9 | |
| SCHEMBL14312617 | 0.80 | HPGDS (0.59) | HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |