Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 6/20 | 0.41 |
| ▸ | KCNT1 | Q5JUK3 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 2/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313148 | 0.90 | HPGDS (0.43) | HPGDSGRIN2BSCN9AWNT3ACSNK1D | |
| SCHEMBL14312653 | 0.88 | HPGDS (0.49) | HPGDSHTR2AHTR2CHTR2BS1PR1 | |
| SCHEMBL14313160 | 0.87 | HPGDS (0.39) | HPGDSKCNT1CYP1A2HTR2AHTR2C | |
| SCHEMBL14313197 | 0.87 | HPGDS (0.40) | HPGDSKCNT1CYP1A2HTR2AHTR2C | |
| SCHEMBL14312801 | 0.86 | HPGDS (0.40) | HPGDSKCNT1CYP1A2HTR2AHTR2C | |
| SCHEMBL14312884 | 0.84 | HPGDS (0.39) | HPGDSCYP1A2RORCPTGS2 | |
| SCHEMBL14313041 | 0.83 | HPGDS (0.38) | HPGDSHTR2AHTR2CHTR2BRORC | |
| SCHEMBL14312864 | 0.83 | HPGDS (0.39) | HPGDSS1PR1RORC | |
| SCHEMBL14312848 | 0.82 | HPGDS (0.39) | HPGDSKCNT1CYP1A2GRIN2BCSNK1D | |
| SCHEMBL14313134 | 0.82 | HPGDS (0.41) | HPGDSGRIN2BWNT3ACSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |