Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 4/20 | 0.32 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14312836 | 0.93 | TGFBR1 (0.32) | TGFBR1TGFBR2 | |
| SCHEMBL14313407 | 0.93 | HPGDS (0.30) | HPGDS | |
| SCHEMBL14313154 | 0.93 | NTRK1 (0.31) | TGFBR1TGFBR2 | |
| SCHEMBL14313327 | 0.89 | HPGDS (0.31) | HPGDS | |
| SCHEMBL14313194 | 0.89 | HPGDS (0.36) | TGFBR1TGFBR2HPGDS | |
| SCHEMBL14312622 | 0.88 | MAPK8 (0.32) | TGFBR1TGFBR2 | |
| SCHEMBL14313250 | 0.87 | HPGDS (0.37) | TGFBR1TGFBR2HPGDS | |
| SCHEMBL14312571 | 0.86 | HPGDS (0.40) | HPGDS | |
| SCHEMBL14313093 | 0.86 | — | — | |
| SCHEMBL14313200 | 0.86 | MAPK8 (0.32) | TGFBR1TGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |