Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 3/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14312871 | 0.93 | HPGDS (0.40) | HPGDSCSNK1DALDH1A1PDGFRBPDGFRA | |
| SCHEMBL14312998 | 0.89 | HPGDS (0.38) | HPGDSCSNK1DALDH1A1PDGFRBPDGFRA | |
| SCHEMBL14313146 | 0.88 | HPGDS (0.38) | HPGDSCSNK1DPDGFRBPDGFRAMAPT | |
| SCHEMBL14312850 | 0.87 | CSNK1D (0.39) | HPGDSCSNK1DALDH1A1KDM4EHPGD | |
| SCHEMBL14312863 | 0.85 | HPGDS (0.41) | HPGDSCSNK1DPDGFRBPDGFRAWNT3A | |
| SCHEMBL14312798 | 0.85 | HPGDS (0.42) | HPGDSCSNK1DPDGFRBPDGFRAWNT3A | |
| SCHEMBL12083980 | 0.83 | HPGDS (0.52) | HPGDSCSNK1DALDH1A1KDM4EHPGD | |
| SCHEMBL14313176 | 0.83 | LMNA (0.39) | HPGDSMAPTLMNA | |
| SCHEMBL14313255 | 0.81 | HPGDS (0.42) | HPGDSCSNK1DPDGFRBPDGFRAWNT3A | |
| SCHEMBL3716064 | 0.81 | HPGDS (0.42) | HPGDSCSNK1DALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |