Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 4/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14312998 | 0.93 | HPGDS (0.38) | HPGDSCSNK1DWNT3APDGFRBPDGFRA | |
| SCHEMBL14312772 | 0.93 | HPGDS (0.40) | HPGDSCSNK1DWNT3APDGFRBPDGFRA | |
| SCHEMBL14313146 | 0.92 | HPGDS (0.38) | HPGDSCSNK1DPDGFRBPDGFRAKCNH2 | |
| SCHEMBL14313176 | 0.90 | LMNA (0.39) | HPGDSMAPTLMNAF10CYP11B1 | |
| SCHEMBL14312733 | 0.87 | CSNK1D (0.39) | HPGDSCSNK1DWNT3AF10CYP11B1 | |
| SCHEMBL14313023 | 0.85 | HPGDS (0.51) | HPGDSMAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL14313255 | 0.85 | HPGDS (0.42) | HPGDSCSNK1DWNT3APDGFRBPDGFRA | |
| SCHEMBL12083549 | 0.83 | HPGDS (0.52) | HPGDSCSNK1DWNT3APDE10AMAPT | |
| SCHEMBL14312863 | 0.81 | HPGDS (0.41) | HPGDSCSNK1DWNT3APDGFRBPDGFRA | |
| SCHEMBL14313439 | 0.81 | HPGDS (0.54) | HPGDSCSNK1DWNT3APDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |