Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 4/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 5/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14312801 | 0.89 | HPGDS (0.40) | HPGDSDGAT2ELANECSNK2A2CSNK2B | |
| SCHEMBL14313171 | 0.89 | HPGDS (0.46) | HPGDSDGAT2GRIN2BGRIN1ELANE | |
| SCHEMBL14313267 | 0.88 | HPGDS (0.43) | HPGDSELANENTRK1 | |
| SCHEMBL14313359 | 0.86 | HPGDS (0.40) | HPGDSDGAT2GRIN2BGRIN1CSNK2A2 | |
| SCHEMBL14313346 | 0.85 | HPGDS (0.41) | HPGDSGRIN2BCSNK1DWNT3A | |
| SCHEMBL14313160 | 0.85 | HPGDS (0.39) | HPGDSDGAT2ELANECSNK2A2CSNK2B | |
| SCHEMBL14313343 | 0.84 | HPGDS (0.44) | HPGDSDGAT2GRIN2BGRIN1CSNK2A2 | |
| SCHEMBL14312736 | 0.83 | PTGER1 (0.31) | HPGDS | |
| SCHEMBL14312398 | 0.83 | HPGDS (0.38) | HPGDSGRIN2BGRIN1CSNK1D | |
| SCHEMBL14313349 | 0.83 | HPGDS (0.32) | HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |