Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.40 |
| ▸ | DGAT2 | Q96PD7 | 5/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313343 | 0.91 | HPGDS (0.44) | HPGDSDGAT2ROCK2GRIN2BGRIN1 | |
| SCHEMBL14313160 | 0.89 | HPGDS (0.39) | HPGDSDGAT2ROCK2CSNK2A2CSNK2B | |
| SCHEMBL14312840 | 0.86 | HPGDS (0.38) | HPGDSDGAT2ROCK2GRIN2BGRIN1 | |
| SCHEMBL14312955 | 0.86 | HPGDS (0.42) | HPGDSCSNK1DWNT3AMAPTLMNA | |
| SCHEMBL14313171 | 0.86 | HPGDS (0.46) | HPGDSDGAT2ROCK2GRIN2BGRIN1 | |
| SCHEMBL12083974 | 0.86 | HPGDS (0.51) | HPGDSDGAT2ROCK2GRIN2BGRIN1 | |
| SCHEMBL14312398 | 0.85 | HPGDS (0.38) | HPGDSGRIN2BGRIN1CSNK1D | |
| SCHEMBL14312563 | 0.84 | HPGDS (0.41) | HPGDSGRIN2BGRIN1CSNK1DCSNK2A2 | |
| SCHEMBL14312693 | 0.83 | HPGDS (0.46) | HPGDSMAPTLMNA | |
| SCHEMBL14312801 | 0.83 | HPGDS (0.40) | HPGDSDGAT2CSNK2A2CSNK2BWNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |