Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 3/20 | 0.38 |
| ▸ | ICMT | O60725 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | MAT2A | P31153 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | GCGR | P47871 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313001 | 0.88 | HPGDS (0.43) | HPGDSAKR1C3AKR1C2 | |
| SCHEMBL14312848 | 0.87 | HPGDS (0.39) | HPGDSPTGS2GRIN2BCSNK1DPTGS1 | |
| SCHEMBL12084151 | 0.86 | HPGDS (0.51) | HPGDSICMTPTGS2DHODHGRIN2B | |
| SCHEMBL14313346 | 0.85 | HPGDS (0.41) | HPGDSICMTGRIN2BCSNK1DHCRTR1 | |
| SCHEMBL14313161 | 0.85 | HPGDS (0.48) | HPGDSPTGS2 | |
| SCHEMBL14313359 | 0.85 | HPGDS (0.40) | HPGDSGRIN2BGRIN1CSNK1D | |
| SCHEMBL14312968 | 0.84 | HPGDS (0.40) | HPGDSICMTGRIN2BCSNK1DHCRTR1 | |
| SCHEMBL14312407 | 0.83 | HPGDS (0.39) | HPGDSPTGS2DHODHGRIN2BGRIN1 | |
| SCHEMBL14313340 | 0.83 | MAPK9 (0.35) | HPGDS | |
| SCHEMBL14312840 | 0.83 | HPGDS (0.38) | HPGDSGRIN2BGRIN1CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |