Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 5/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 9/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313256 | 0.90 | HPGDS (0.52) | HPGDSL3MBTL1ALDH1A1KDM4ETRPM8 | |
| SCHEMBL14313421 | 0.85 | CYP1A2 (0.38) | HPGDSALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL14313311 | 0.85 | HPGDS (0.47) | HPGDSL3MBTL1ALDH1A1KDM4ETRPM8 | |
| SCHEMBL14312671 | 0.85 | HPGDS (0.46) | HPGDSL3MBTL1ALDH1A1KDM4ETRPM8 | |
| SCHEMBL14313273 | 0.85 | HPGDS (0.58) | HPGDSL3MBTL1ALDH1A1KDM4ETRPM8 | |
| SCHEMBL14313361 | 0.83 | HPGDS (0.60) | HPGDSL3MBTL1ALDH1A1KDM4ETRPM8 | |
| SCHEMBL14313445 | 0.83 | HPGDS (0.54) | HPGDSL3MBTL1ALDH1A1KDM4ETRPM8 | |
| SCHEMBL3219730 | 0.83 | HPGDS (0.70) | HPGDSALDH1A1KDM4ETRPM8HTT | |
| SCHEMBL14312952 | 0.82 | HPGDS (0.50) | HPGDSL3MBTL1ALDH1A1KDM4ETRPM8 | |
| SCHEMBL14313134 | 0.82 | HPGDS (0.41) | HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |