Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 4/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 9/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14312798 | 0.88 | HPGDS (0.42) | HPGDSGRIN2BPDGFRBPDGFRACSNK1D | |
| SCHEMBL14313421 | 0.87 | CYP1A2 (0.38) | HPGDS | |
| SCHEMBL14313159 | 0.87 | HPGDS (0.39) | HPGDSGRIN2BCSNK1D | |
| SCHEMBL14312696 | 0.86 | HPGDS (0.43) | HPGDSGRIN2BPDGFRBPDGFRACSNK1D | |
| SCHEMBL14313002 | 0.86 | HPGDS (0.41) | HPGDSPDGFRBPDGFRACSNK1DWNT3A | |
| SCHEMBL14313255 | 0.86 | HPGDS (0.42) | HPGDSGRIN2BPDGFRBPDGFRACSNK1D | |
| SCHEMBL14313268 | 0.86 | HPGDS (0.40) | HPGDSGRIN2BBRD4PDGFRBPDGFRA | |
| SCHEMBL14312563 | 0.86 | HPGDS (0.41) | HPGDSGRIN2BCSNK1DWNT3A | |
| SCHEMBL14312771 | 0.85 | GRIN2B (0.38) | HPGDSGRIN2BWNT3AMET | |
| SCHEMBL14313148 | 0.85 | HPGDS (0.43) | HPGDSGRIN2BPDGFRBPDGFRACSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |