Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 9/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313256 | 0.89 | HPGDS (0.52) | HPGDSL3MBTL1TRPM8ALDH1A1KDM4E | |
| SCHEMBL14313022 | 0.88 | HPGDS (0.45) | HPGDSL3MBTL1TRPM8ALDH1A1KDM4E | |
| SCHEMBL14312654 | 0.85 | HPGDS (0.39) | HPGDSSMN1; SMN2MAPTKMT2ASLC22A12 | |
| SCHEMBL14312911 | 0.85 | HPGDS (0.50) | HPGDSL3MBTL1TRPM8ALDH1A1KDM4E | |
| SCHEMBL14313311 | 0.84 | HPGDS (0.47) | HPGDSL3MBTL1TRPM8ALDH1A1KDM4E | |
| SCHEMBL14312879 | 0.83 | ENPP3 (0.36) | HPGDSL3MBTL1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL14313099 | 0.83 | TGFBR1 (0.36) | HPGDSL3MBTL1ALDH1A1SLC22A12 | |
| SCHEMBL3221680 | 0.82 | HPGDS (0.63) | HPGDSKDM4EMEN1KMT2ASLC22A12 | |
| SCHEMBL14313361 | 0.82 | HPGDS (0.60) | HPGDSL3MBTL1TRPM8ALDH1A1KDM4E | |
| SCHEMBL14313192 | 0.82 | SLC22A12 (0.34) | HPGDSL3MBTL1SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |