Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 4/20 | 0.55 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | F12 | P00748 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 3/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313013 | 0.88 | HPGDS (0.40) | HPGDSPDE10ARAF1NTRK1 | |
| SCHEMBL14312953 | 0.86 | HPGDS (0.73) | HPGDSTRPM8L3MBTL1MEN1ALDH1A1 | |
| SCHEMBL14313196 | 0.83 | HPGDS (0.60) | HPGDSTRPM8L3MBTL1MEN1ALDH1A1 | |
| SCHEMBL14313181 | 0.83 | HPGDS (0.60) | HPGDSTRPM8L3MBTL1MEN1ALDH1A1 | |
| SCHEMBL14313050 | 0.80 | HPGDS (0.57) | HPGDSL3MBTL1MEN1ALDH1A1HTT | |
| SCHEMBL14312957 | 0.79 | HPGDS (0.55) | HPGDSL3MBTL1MEN1ALDH1A1HTT | |
| SCHEMBL14313445 | 0.79 | HPGDS (0.54) | HPGDSTRPM8L3MBTL1MEN1ALDH1A1 | |
| SCHEMBL14313242 | 0.77 | HPGDS (0.60) | HPGDSKCNH2 | |
| SCHEMBL14313042 | 0.77 | HPGDS (0.49) | HPGDSTRPM8L3MBTL1MEN1ALDH1A1 | |
| SCHEMBL14313156 | 0.77 | HPGDS (0.64) | HPGDSL3MBTL1MEN1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |