Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | RAF1 | P04049 | 4/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | PDE1A | P54750 | 2/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | GRM5 | P41594 | 3/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14312950 | 0.88 | HPGDS (0.55) | HPGDSPDE10ARAF1NTRK1 | |
| SCHEMBL14313439 | 0.85 | HPGDS (0.54) | HPGDS | |
| SCHEMBL14312802 | 0.84 | HPGDS (0.44) | HPGDS | |
| SCHEMBL14313280 | 0.84 | MEN1 (0.42) | HPGDSMTOR | |
| SCHEMBL14313322 | 0.82 | HPGDS (0.42) | HPGDSGRM5 | |
| SCHEMBL14313409 | 0.80 | HPGDS (0.43) | HPGDSGRM5 | |
| SCHEMBL14313346 | 0.80 | HPGDS (0.41) | HPGDS | |
| SCHEMBL14312868 | 0.80 | TSHR (0.39) | HPGDSMTORPIK3CA | |
| SCHEMBL14313025 | 0.79 | HPGDS (0.46) | HPGDS | |
| SCHEMBL14312968 | 0.79 | HPGDS (0.40) | HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |