Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 3/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ECE1 | P42892 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.30 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.30 |
| ▸ | DHFR | P00374 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313453 | 0.93 | HPGDS (0.35) | HPGDSBCHEACHEECE1MAPK8 | |
| SCHEMBL14312961 | 0.90 | AGTR2 (0.30) | — | |
| SCHEMBL14313327 | 0.89 | HPGDS (0.31) | HPGDS | |
| SCHEMBL14312951 | 0.89 | HPGDS (0.38) | HPGDS | |
| SCHEMBL14313194 | 0.88 | HPGDS (0.36) | HPGDSBCHEACHEHTR6MAPK8 | |
| SCHEMBL14313345 | 0.88 | HPGDS (0.35) | HPGDSBCHEACHEHTR6 | |
| SCHEMBL14313349 | 0.87 | HPGDS (0.32) | HPGDSMAPK8MAPK9MAPK10 | |
| SCHEMBL14313036 | 0.87 | HPGDS (0.51) | HPGDSBCHEACHEDHFR | |
| SCHEMBL14312819 | 0.87 | AGTR2 (0.31) | HPGDSMAPK8MAPK9MAPK10 | |
| SCHEMBL14313270 | 0.85 | HPGDS (0.32) | HPGDSECE1MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |