Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.30 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | IGF1R | P08069 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14312699 | 0.87 | HPGDS (0.37) | HPGDS | |
| SCHEMBL14313293 | 0.86 | HPGDS (0.44) | HPGDSTGFBR1 | |
| SCHEMBL14313159 | 0.86 | HPGDS (0.39) | HPGDSGRIN1GRIN2BSYK | |
| SCHEMBL14313220 | 0.85 | HPGDS (0.35) | HPGDSHPGDTGFBR1 | |
| SCHEMBL14312817 | 0.84 | HPGDS (0.35) | HPGDS | |
| SCHEMBL14312885 | 0.82 | HPGDS (0.49) | HPGDSKDM4E | |
| SCHEMBL14313410 | 0.82 | HPGDS (0.41) | HPGDSTGFBR1HCRTR1SYK | |
| SCHEMBL14313927 | 0.78 | HPGDS (0.42) | HPGDS | |
| SCHEMBL14312653 | 0.77 | HPGDS (0.49) | HPGDSKDM4EHCRTR1 | |
| SCHEMBL14312911 | 0.77 | HPGDS (0.50) | HPGDSKDM4EALDH1A1HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |