Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MASP2 | O00187 | 4/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1432473 | 0.88 | MASP2 (0.38) | MASP2NAMPT | |
| SCHEMBL1432679 | 0.86 | MASP2 (0.39) | MASP2ADRB2ADRB1ADRB3LMNA | |
| SCHEMBL1431803 | 0.85 | CTSB (0.41) | MASP2 | |
| SCHEMBL1432462 | 0.85 | MASP2 (0.39) | MASP2ADRB2ADRB1ADRB3NAMPT | |
| SCHEMBL1432188 | 0.85 | MASP2 (0.39) | MASP2ADRB2ADRB1ADRB3NAMPT | |
| SCHEMBL1432545 | 0.83 | NAMPT (0.44) | MASP2NAMPT | |
| SCHEMBL1432418 | 0.82 | CHRNA1 (0.41) | MASP2ADRB2ADRB1ADRB3 | |
| SCHEMBL1902822 | 0.82 | BACE1 (0.40) | MASP2ADRB2ADRB1ADRB3NAMPT | |
| SCHEMBL1433148 | 0.81 | MASP2 (0.39) | MASP2NAMPT | |
| SCHEMBL3141395 | 0.80 | CTSB (0.45) | MASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300428-A1 | AMINOPYRIDINE DERIVATIVES | Vantia Limited (GB) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009133348-A1 | AMINOPYRIDINE DERIVATIVES | VANTIA LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |