Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.43 |
| ▸ | CTSL | P07711 | 3/20 | 0.41 |
| ▸ | MASP2 | O00187 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | CPA1 | P15085 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.40 |
| ▸ | FURIN | P09958 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1431886 | 0.90 | PSMB5 (0.49) | MAPK14PSMB5F2PSMB1CTSL | |
| SCHEMBL1432540 | 0.89 | MASP2 (0.43) | MASP2PLGKLKB1 | |
| SCHEMBL1432156 | 0.88 | MASP2 (0.45) | CTSLMASP2PLGKLKB1 | |
| SCHEMBL1432206 | 0.86 | MASP2 (0.51) | MASP2MMEACECPA1ACE2 | |
| SCHEMBL3145343 | 0.86 | MAPK14 (0.45) | MAPK14PSMB5F2CTSLMASP2 | |
| SCHEMBL1432380 | 0.86 | MAPK14 (0.45) | MAPK14PSMB5F2CTSLMASP2 | |
| SCHEMBL3147894 | 0.86 | MAPK14 (0.44) | MAPK14PSMB5F2CTSLMASP2 | |
| SCHEMBL1432194 | 0.86 | MAPK14 (0.44) | MAPK14PSMB5F2CTSLMASP2 | |
| SCHEMBL1431687 | 0.85 | MME (0.44) | PSMB5PSMB1MASP2PLGMME | |
| SCHEMBL1431642 | 0.85 | MME (0.44) | PSMB5PSMB1MASP2PLGMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300428-A1 | AMINOPYRIDINE DERIVATIVES | Vantia Limited (GB) | 2011-03-30 | — | — | EP | disclosed |