Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 5/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 3/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | CPA1 | P15085 | 1/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.39 |
| ▸ | FURIN | P09958 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.39 |
| ▸ | MASP2 | O00187 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1432193 | 0.90 | MAPK14 (0.45) | PSMB5MAPK14PSMB1F2CTSL | |
| SCHEMBL1432034 | 0.87 | CTSB (0.43) | CTSLKLKB1MASP2 | |
| SCHEMBL1432562 | 0.85 | MME (0.43) | PSMB5PSMB1MMEACECPA1 | |
| SCHEMBL1432022 | 0.85 | MME (0.43) | PSMB5PSMB1MMEACECPA1 | |
| SCHEMBL1432380 | 0.85 | MAPK14 (0.45) | PSMB5MAPK14F2CTSLPLG | |
| SCHEMBL3145343 | 0.85 | MAPK14 (0.45) | PSMB5MAPK14F2CTSLPLG | |
| SCHEMBL1432883 | 0.85 | FURIN (0.40) | PSMB5MMEACECPA1ACE2 | |
| SCHEMBL1432300 | 0.85 | MASP2 (0.40) | MMEACECPA1ACE2FURIN | |
| SCHEMBL1431636 | 0.84 | MME (0.43) | MMEACECPA1ACE2FURIN | |
| SCHEMBL1432194 | 0.84 | MAPK14 (0.44) | PSMB5MAPK14F2CTSLPLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300428-A1 | AMINOPYRIDINE DERIVATIVES | Vantia Limited (GB) | 2011-03-30 | — | — | EP | disclosed |