Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.38 |
| ▸ | MASP2 | O00187 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | FURIN | P09958 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1902789 | 0.90 | NAMPT (0.44) | AAK1MASP2HDAC1NAMPTGRM2 | |
| SCHEMBL1901340 | 0.87 | PDPK1 (0.39) | PDPK1MASP2NAMPTFURIN | |
| SCHEMBL1432325 | 0.85 | PDPK1 (0.40) | PDPK1MASP2NAMPTFURIN | |
| SCHEMBL1902374 | 0.84 | PDPK1 (0.40) | PDPK1MASP2NAMPTFURIN | |
| SCHEMBL1903653 | 0.84 | PDPK1 (0.40) | PDPK1MASP2NAMPTFURIN | |
| SCHEMBL1901478 | 0.83 | AAK1 (0.38) | AAK1PDPK1ALOX5APFEN1S1PR3 | |
| SCHEMBL1907783 | 0.83 | PDPK1 (0.38) | PDPK1MASP2HDAC1NAMPT | |
| SCHEMBL1431876 | 0.83 | MASP2 (0.43) | PDPK1MASP2NAMPT | |
| SCHEMBL1902464 | 0.83 | MASP2 (0.39) | PDPK1MASP2NAMPTFURIN | |
| SCHEMBL1899812 | 0.83 | MASP2 (0.39) | PDPK1MASP2NAMPTFURIN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |
| EP-2300428-A1 | AMINOPYRIDINE DERIVATIVES | Vantia Limited (GB) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009133348-A1 | AMINOPYRIDINE DERIVATIVES | VANTIA LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |