Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.38 |
| ▸ | MASP2 | O00187 | 3/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | TLR2 | O60603 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1904386 | 0.89 | NAMPT (0.45) | MASP2NAMPTMEN1KMT2A | |
| SCHEMBL1903992 | 0.89 | NAMPT (0.42) | PDPK1MASP2NAMPTMETTLR2 | |
| SCHEMBL1899812 | 0.89 | MASP2 (0.39) | PDPK1MASP2NAMPTTLR2BACE1 | |
| SCHEMBL1902464 | 0.89 | MASP2 (0.39) | PDPK1MASP2NAMPTTLR2BACE1 | |
| SCHEMBL1902876 | 0.88 | BACE1 (0.40) | PDPK1MASP2NAMPTBACE1HDAC1 | |
| SCHEMBL1901316 | 0.87 | CA2 (0.40) | PDPK1 | |
| SCHEMBL1431876 | 0.86 | MASP2 (0.43) | PDPK1MASP2NAMPTTLR2BACE1 | |
| SCHEMBL1901340 | 0.85 | PDPK1 (0.39) | PDPK1MASP2NAMPTTLR2BACE1 | |
| SCHEMBL1432265 | 0.84 | PDPK1 (0.35) | PDPK1MASP2NAMPTKCNQ2MET | |
| SCHEMBL1432510 | 0.84 | MASP2 (0.38) | PDPK1MASP2NAMPTBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | claimed |
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |