Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MASP2 | O00187 | 3/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | KLK1 | P06870 | 3/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1433148 | 0.90 | MASP2 (0.39) | MASP2BACE1BACE2KLKB1OPRM1 | |
| SCHEMBL1907931 | 0.88 | BACE1 (0.40) | MASP2BACE1BACE2KLKB1CTSD | |
| SCHEMBL1431704 | 0.88 | MASP2 (0.43) | MASP2BACE1BACE2KLKB1NAMPT | |
| SCHEMBL1432280 | 0.83 | KLKB1 (0.49) | MASP2KLKB1KLK1 | |
| SCHEMBL1431986 | 0.83 | MASP2 (0.42) | MASP2BACE1BACE2NAMPTF2 | |
| SCHEMBL3145480 | 0.83 | KLKB1 (0.49) | MASP2KLKB1KLK1 | |
| SCHEMBL1431488 | 0.81 | MALT1 (0.39) | MASP2 | |
| SCHEMBL1901816 | 0.81 | MASP2 (0.39) | MASP2CPB2 | |
| SCHEMBL1432381 | 0.81 | KLKB1 (0.39) | MASP2BACE1BACE2KLKB1CTSD | |
| SCHEMBL1432596 | 0.81 | MASP2 (0.39) | MASP2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300428-A1 | AMINOPYRIDINE DERIVATIVES | Vantia Limited (GB) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009133348-A1 | AMINOPYRIDINE DERIVATIVES | VANTIA LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |