Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MASP2 | O00187 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
| ▸ | GABRE | P78334 | 1/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.35 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.35 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.35 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.35 |
| ▸ | F2R | P25116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1432473 | 0.89 | MASP2 (0.38) | MASP2TSHRF7FURINCPB2 | |
| SCHEMBL1432596 | 0.88 | MASP2 (0.39) | MASP2TSHRF2RFURINKCNH2 | |
| SCHEMBL1899812 | 0.86 | MASP2 (0.39) | MASP2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL1902464 | 0.86 | MASP2 (0.39) | MASP2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL1904701 | 0.85 | NAMPT (0.45) | MASP2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL1907931 | 0.84 | BACE1 (0.40) | MASP2CPB2 | |
| SCHEMBL1431488 | 0.83 | MALT1 (0.39) | MASP2KCNH2 | |
| SCHEMBL1431704 | 0.82 | MASP2 (0.43) | MASP2CPB2 | |
| SCHEMBL1432287 | 0.81 | MASP2 (0.39) | MASP2CPB2 | |
| SCHEMBL1431986 | 0.81 | MASP2 (0.42) | MASP2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | claimed |