SCHEMBL143240

SCHEMBL143240

Nc1cn(-c2ccccc2C(=O)c2ccccc2)c2ccccc12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.50
GAA P10253 1/20 0.50
POLB P06746 3/20 0.49
CA12 O43570 2/20 0.48
CA9 Q16790 2/20 0.48
CA1 P00915 1/20 0.48
CA2 P00918 1/20 0.48
ALDH1A1 P00352 2/20 0.47
HSP90AA1 P07900 1/20 0.47
PKM P14618 1/20 0.47
CCR6 P51684 1/20 0.47
ATM Q13315 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
TLR9 Q9NR96 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
RORC P51449 5/20 0.46
KMT2A Q03164 1/20 0.46
AKR1C3 P42330 1/20 0.45
SRC P12931 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3408328 0.84 POLB (0.50) MAPTGAAPOLBCA12CA9
SCHEMBL13010120 0.83 ALDH1A1 (0.36) MAPTGAAPOLBCA12CA9
SCHEMBL150147 0.79 MAPK1 (0.49) MAPTPOLBCA12CA9CA1
SCHEMBL17850892 0.75 ALDH1A1 (0.72) MAPTGAAPOLBALDH1A1HSP90AA1
SCHEMBL152924 0.75 RORC (0.46) POLBALDH1A1HSP90AA1PKMCCR6
SCHEMBL152899 0.75 HSP90AA1 (0.50) MAPTGAAPOLBALDH1A1HSP90AA1
SCHEMBL142554 0.72 POLB (0.49) MAPTPOLBALDH1A1NPSR1KMT2A
SCHEMBL14176088 0.72 RORC (0.58) CA12CA9CA1CA2NPSR1
SCHEMBL23292905 0.71 CA12 (0.72) POLBCA12CA9CA1CA2
SCHEMBL3409491 0.70 ALDH1A1 (0.43) POLBALDH1A1HSP90AA1PKMCCR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8940909-B2 Indicator platform BIOSYNTH AG (CH) 2015-01-27 US disclosed
US-8940909-B2 Indicator platform BIOSYNTH AG (CH) 2015-01-27 US disclosed
US-8940909-B2 Indicator platform BIOSYNTH AG (CH) 2015-01-27 US disclosed
CN-102459168-B novel indicator platform BIOSINT S.P.A. (CH) 2014-10-01 CN disclosed
EP-2427431-B1 NOVEL INDICATOR PLATFORM BIOSYNTH AG (CH) 2013-05-01 EP disclosed
CN-102459168-A Novel indicator platform BIOSYNTH AG 2012-05-16 CN disclosed
EP-2427431-A1 NOVEL INDICATOR PLATFORM Biosynth AG (CH) 2012-03-14 EP disclosed
US-20120058503-A1 Novel Indicator Platform BIOSYNTH AG (CH) 2012-03-08 US disclosed
US-20120058503-A1 Novel Indicator Platform BIOSYNTH AG (CH) 2012-03-08 US disclosed
US-20120058503-A1 Novel Indicator Platform BIOSYNTH AG (CH) 2012-03-08 US disclosed
EP-2256103-A1 Novel indicator platform Biosynth AG (CH) 2010-12-01 EP disclosed
WO-2010128120-A1 NOVEL INDICATOR PLATFORM BIOSYNTH AG (CH) 2010-11-11 WO disclosed
WO-2010128120-A1 NOVEL INDICATOR PLATFORM BIOSYNTH AG (CH) 2010-11-11 WO disclosed