Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.86 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.86 |
| ▸ | LMNA | P02545 | 3/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.86 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.86 |
| ▸ | ACHE | P22303 | 4/20 | 0.41 |
| ▸ | APEX1 | P27695 | 3/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL30589345 | 1.00 | MEN1 (0.86) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL31315413 | 1.00 | — | — | |
| Choline SCHEMBL54947 | 1.00 | — | — | |
| Choline SCHEMBL28050384 | 0.96 | — | — | |
| Choline SCHEMBL10779307 | 0.96 | CYP3A4 (0.93) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL27565807 | 0.96 | — | — | |
| Choline SCHEMBL1934626 | 0.96 | MEN1 (0.80) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL2678893 | 0.96 | — | — | |
| Choline SCHEMBL20490075 | 0.96 | MEN1 (0.80) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL396926 | 0.96 | MEN1 (0.80) | MEN1KMT2ALMNACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240101593-A1 | URSOLIC ACID PREPARATIONS AND USES THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY | 2024-03-28 | — | — | US | claimed |
| CN-109694091-B | Preparation method of IWR/CDO cocrystallized zeolite molecular sieve | 中国石油化工股份有限公司 | 2020-10-30 | — | — | CN | claimed |
| US-12522632-B2 | Method for extracting keratin from wool/natural fibers using ionic liquids reinforced with sonication | Najran University (SA) | 2026-01-13 | — | — | US | disclosed |
| EP-3844142-B1 | QUATERNARY AMMONIUM HYDROXIDES OF POLYAMINES | HUNTSMAN PETROCHEMICAL LLC (US) | 2024-09-11 | — | — | EP | disclosed |
| US-20240239837-A1 | METHOD FOR EXTRACTING KERATIN FROM WOOL/NATURAL FIBERS USING IONIC LIQUIDS REINFORCED WITH SONICATION | Najran University (SA) | 2024-07-18 | — | — | US | disclosed |
| US-11643384-B2 | Stabilization of compositions comprising quaternary trialkylalkanolamine hydroxide | KURITA WATER INDUSTRIES LTD. (JP) | 2023-05-09 | — | — | US | disclosed |
| CN-115925650-A | Epalrestat eutectic crystal and preparation method and application thereof | 山东达因海洋生物制药股份有限公司 | 2023-04-07 | — | — | CN | disclosed |
| EP-3784817-B1 | STABILIZATION OF COMPOSITIONS COMPRISING QUATERNARY TRIALKYLALKANOLAMINE HYDROXIDE | KURITA WATER IND LTD (JP) | 2022-04-20 | — | — | EP | disclosed |
| US-20210061754-A1 | STABILIZATION OF COMPOSITIONS COMPRISING QUATERNARY TRIALKYLALKANOLAMINE HYDROXIDE | KURITA WATER INDUSTRIES LTD. (JP) | 2021-03-04 | — | — | US | disclosed |
| EP-3784817-A1 | STABILIZATION OF COMPOSITIONS COMPRISING QUATERNARY TRIALKYLALKANOLAMINE HYDROXIDE | Kurita Water Industries Ltd. (JP) | 2021-03-03 | — | — | EP | disclosed |
| CN-109694091-B | Preparation method of IWR/CDO cocrystallized zeolite molecular sieve | 中国石油化工股份有限公司 | 2020-10-30 | — | — | CN | disclosed |
| US-20120058276-A1 | SOLUTION FOR PROCESSING OF METAL REPLACEMENT WITH METAL ALUMINUM OR ALUMINUM ALLOY AND METHOD FOR SURFACE PROCESSING USING SUCH SOLUTION | C. UYEMURA & CO., LTD. (JP) | 2012-03-08 | — | — | US | disclosed |
| US-8101561-B2 | Composition and method for treating semiconductor substrate surface | LASERWORT LTD (HK) | 2012-01-24 | — | — | US | disclosed |
| US-20110118165-A1 | COMPOSITION AND METHOD FOR TREATING SEMICONDUCTOR SUBSTRATE SURFACE | Lee, Wai Mun (US) | 2011-05-19 | — | — | US | disclosed |
| US-20080139436-A1 | Two step cleaning process to remove resist, etch residue, and copper oxide from substrates having copper and low-K dielectric material | EKC TECHNOLOGY, INC. | 2008-06-12 | — | — | US | disclosed |
| US-20070254822-A1 | Method for Producing Quaternary Ammonium Compounds | BASF AKTIENGESELLSCHAFT (DE) | 2007-11-01 | — | — | US | disclosed |
| CN-100341992-C | Composition and method for removing residues from semiconductor manufacturing | EKC TECHNOLOGY INC (US) | 2007-10-10 | — | — | CN | disclosed |
| EP-1753711-A1 | METHOD FOR PRODUCING QUATERNARY AMMONIUM COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005115969-A1 | METHOD FOR PRODUCING QUATERNARY AMMONIUM COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2005-12-08 | — | — | WO | disclosed |
| CN-1465687-A | Composition and method for removing residues from semiconductor manufacturing | EKC������˾ | 2004-01-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240101593-A1 | URSOLIC ACID PREPARATIONS AND USES THEREOF | ULK2, UTS2R, UCK2 | MEN1 2319/4885KMT2A 4229/4885LMNA 3286/4885 |
| US-20240239837-A1 | METHOD FOR EXTRACTING KERATIN FROM WOOL/NATURAL FIBERS USING IONIC LIQUIDS REINFORCED WITH SONICATION | KRT18, CKAP4, ANKK1 | MEN1 4358/4885KMT2A 1643/4885LMNA 465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.